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  4. Systematically Designed Periodic Electrophoretic Deposition for Decorating 3D Carbon-Based Scaffolds with Bioactive Nanoparticles
 
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Systematically Designed Periodic Electrophoretic Deposition for Decorating 3D Carbon-Based Scaffolds with Bioactive Nanoparticles

Publikationstyp
Journal Article
Date Issued
2019-09-09
Sprache
English
Author(s)
Taale, Mohammadreza  
Krüger, Diana  
Ossei-Wusu, Emmanuel  
Schütt, Fabian  
Rehman, Muhammad Atiq Ur  
Mishra, Yogendra Kumar  
Marx, Janik  
Stock, Norbert  
Fiedler, Bodo  orcid-logo
Boccaccini, Aldo R  
Willumeit-Römer, Regine  
Adelung, Rainer  
Selhuber-Unkel, Christine  
Institut
Kunststoffe und Verbundwerkstoffe M-11  
TORE-URI
http://hdl.handle.net/11420/3624
Journal
ACS biomaterials science & engineering  
Volume
5
Issue
9
Start Page
4393
End Page
4404
Citation
ACS Biomaterials Science and Engineering 9 (5): 4393-4404 (2019-09-09)
Publisher DOI
10.1021/acsbiomaterials.9b00102
Scopus ID
2-s2.0-85070717443
The coating of porous scaffolds with nanoparticles is crucial in many applications, for example to generate scaffolds for catalysis or to make scaffolds bioactive. A standard and well-established method for coating surfaces with charged nanoparticles is electrophoresis, but when used on porous scaffolds, this method often leads to a blockage of the pores so that only the outermost layers of the scaffolds are coated. In this study, the electrophoretic coating process is monitored in situ and the kinetics of nanoparticle deposition are investigated. This concept can be extended to design a periodic electrophoretic deposition (PEPD) strategy, thus avoiding the typical blockage of surface pores. In the present work we demonstrate successful and homogeneous electrophoretic deposition of hydroxyapatite nanoparticles (HAn, diameter ≤200 nm) on a fibrous graphitic 3D structure (ultralightweight aerographite) using the PEPD strategy. The microfilaments of the resulting scaffold are covered with HAn both internally and on the surface. Furthermore, protein adsorption assays and cell proliferation assays were carried out and revealed that the HAn-decorated aerographite scaffolds are biocompatible. The HAn decoration of the scaffolds also significantly increases the alkaline phosphatase activity of osteoblast cells, showing that the scaffolds are able to promote their osteoblastic activity.
Subjects
3D scaffold
aerographite
electrophoretic deposition
hydroxyapatite
osteoblasts
tissue engineering
More Funding Information
DFG: RTG 2154, SFB 1261 project B7
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