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Entwicklung der Epidemiologie und der jahreszeitlichen Abhängigkeit des Vitamin-D-Status in Deutschland in den Jahren 2007 bis 2019
Citation Link: https://doi.org/10.15480/882.2807
Publikationstyp
Master Thesis
Date Issued
2020-06-24
Sprache
German
Author(s)
Other Contributor
Pörtner, Ralf
Other Contributor
Advisor
Pörtner, Ralf
Referee
Title Granting Institution
Technische Universität Hamburg
Place of Title Granting Institution
Hamburg
Examination Date
2020-05-08
TORE-DOI
TORE-URI
Citation
Technische Universität Hamburg (2020)
Vitamin D plays a central role in numerous physiological functions and is associated with some acute and chronic diseases. Vitamin D deficiency is now recognised as a global pandemic.
The development of the epidemiology and seasonal dependence of the vitamin D status in Germany in the years 2007 to 2019 is presented and statistically analysed on the basis of 2,008,566 vitamin D laboratory data and 380,024 calcium laboratory data from four cohorts. The general course of the vitamin D status and the influence of monthly fluctuations, gender and age on the vitamin D level are investigated. A linear model for vitamin D levels is established as a function of year, age and sex. The incidence of critically high vitamin D levels and associated hypercalcemia is investigated. The general influence of vitamin D levels on calcium levels and calcium deficiency is also analysed.
The majority of the entire population still has a vitamin D deficiency and a large proportion even has a severe vitamin D deficiency. A clear influence of the seasons in the form of a monthly fluctuation of vitamin D levels within the years and cohorts was found. The sex and age of the patients were identified as influencing factors for the mean vitamin D level as well as the development of the vitamin D level over the period 2007 to 2019. Especially the independent supplementation through increased health awareness seems to be an effective measure against vitamin D deficiency. The influence of high vitamin D levels on the incidence of hypercalcemia is not statistically significant based on the data. Given the high potential for health, intervention studies should be designed to end the vitamin D pandemic.
The development of the epidemiology and seasonal dependence of the vitamin D status in Germany in the years 2007 to 2019 is presented and statistically analysed on the basis of 2,008,566 vitamin D laboratory data and 380,024 calcium laboratory data from four cohorts. The general course of the vitamin D status and the influence of monthly fluctuations, gender and age on the vitamin D level are investigated. A linear model for vitamin D levels is established as a function of year, age and sex. The incidence of critically high vitamin D levels and associated hypercalcemia is investigated. The general influence of vitamin D levels on calcium levels and calcium deficiency is also analysed.
The majority of the entire population still has a vitamin D deficiency and a large proportion even has a severe vitamin D deficiency. A clear influence of the seasons in the form of a monthly fluctuation of vitamin D levels within the years and cohorts was found. The sex and age of the patients were identified as influencing factors for the mean vitamin D level as well as the development of the vitamin D level over the period 2007 to 2019. Especially the independent supplementation through increased health awareness seems to be an effective measure against vitamin D deficiency. The influence of high vitamin D levels on the incidence of hypercalcemia is not statistically significant based on the data. Given the high potential for health, intervention studies should be designed to end the vitamin D pandemic.
Subjects
Vitamin D 3
Vitamin D
25‐hydroxyvitamin D
vitamin D deficiency
Vitamin D supplementation
DDC Class
570: Biowissenschaften, Biologie
610: Medizin
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Name
2020-04-19 Masterarbeit Vitamin D Göthel.pdf
Size
3.91 MB
Format
Adobe PDF