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Review on the impact of impeller‐induced hydrodynamics on suspension cell culture for production of biopharmaceuticals
Citation Link: https://doi.org/10.15480/882.9487
Publikationstyp
Review Article
Date Issued
2024-02-20
Sprache
English
TORE-DOI
Journal
Volume
96
Issue
4
Start Page
462
End Page
470
Citation
Chemie Ingenieur Technik 96 (4): 462-470 (2024-02-20)
Publisher DOI
Scopus ID
Publisher
Wiley-VCH
Hydrodynamic effects continue to play a crucial role in the design and operation of bioreactors for cultivating mammalian cells. Despite intensive studies in the past the link between hydrodynamics and biological process behaviour is still not fully understood. Common methods to describe dependencies, which relay mostly on averaged hydrodynamic parameters, does not seem to be suitable, as they do not incorporate the hydrodynamic heterogeneity. Within this review first a brief introduction to hydrodynamic effects is given, followed by an evaluation of common process design approaches with respect to hydrodynamic effects and recommendations for process development.
Subjects
Bioreactor characterization
Computational fluid dynamics
Energy dissipation rate
Kolmogorov length scale
Mammalian cell culture
Operational space
Process development
Shear effects
DDC Class
620: Engineering
530: Physics
Publication version
publishedVersion
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Name
CITE_CITE202300162.pdf
Type
Main Article
Size
1.86 MB
Format
Adobe PDF