Review on the impact of impeller‐induced hydrodynamics on suspension cell culture for production of biopharmaceuticals

Enthalten in
Chemie - Ingenieur - Technik 
Volume
96
Issue
4
Start Page
462
End Page
470
Citation
Chemie Ingenieur Technik 96 (4): 462-470 (2024-02-20)
Publisher DOI
10.1002/cite.202300162
Scopus ID
2-s2.0-85185279491
Publisher
Wiley-VCH
Hydrodynamic effects continue to play a crucial role in the design and operation of bioreactors for cultivating mammalian cells. Despite intensive studies in the past the link between hydrodynamics and biological process behaviour is still not fully understood. Common methods to describe dependencies, which relay mostly on averaged hydrodynamic parameters, does not seem to be suitable, as they do not incorporate the hydrodynamic heterogeneity. Within this review first a brief introduction to hydrodynamic effects is given, followed by an evaluation of common process design approaches with respect to hydrodynamic effects and recommendations for process development.
Schlagworte
Bioreactor characterization
Computational fluid dynamics
Energy dissipation rate
Kolmogorov length scale
Mammalian cell culture
Operational space
Process development
Shear effects
DDC Class
620: Engineering
530: Physics
Projekt(e)
Projekt DEAL 
Publication version
publishedVersion
Lizenz
https://creativecommons.org/licenses/by/4.0/
Thumbnail Image
Name

CITE_CITE202300162.pdf

Type

main article

Size

1.86 MB

Format

Adobe PDF