Enabling technologies towards personalization of scaffolds for large bone defect regeneration

Publikationstyp
Review Article
Date Issued
2022-04-01
Sprache
English
Author(s)
Poh, Patrina Su Ping  
Lingner, Thomas
Kalkhof, Stefan
Märdian, Sven
Baumbach, Jan
Dondl, Patrick
Duda, Georg  
Checa Esteban, Sara  
TORE-URI
https://hdl.handle.net/11420/48135
Journal
Current opinion in biotechnology  
Volume
74
Start Page
263
End Page
270
Citation
Current Opinion in Biotechnology 74: 263-270 (2022)
Publisher DOI
10.1016/j.copbio.2021.12.002
Scopus ID
2-s2.0-85122458337
Publisher
Elsevier
Additive manufacturing (AM) can deliver personalized scaffolds to support large volume defect tissue regeneration — a major clinical challenge in many medical disciplines. The freedom in scaffold design and composition (biomaterials and biologics) offered by AM yields a plethora of possibilities but is confronted with a heterogenous biological regeneration potential across individuals. A key challenge is to make the right choice for individualized scaffolds that match biology, anatomy, and mechanics of patients. This review provides an overview of state-of-the-art technologies, that is, in silico modelling for scaffold design, omics and bioinformatics to capture patient biology and information technology for data management, that, when combined in a synergistic way with AM, have great potential to make personalized tissue regeneration strategies available to all patients, empowering precision medicine.
DDC Class
610: Medicine, Health