Alcohol dehydrogenases have been immobilized adsorptivly and covalently on surface modified particles (modified through the layer-by-layer technique,e.g. polyethylene imine). The immobilized enzymes have been subsequently applied in a plug-flow reactor to produce short chain alcohols (2,5-hexanediol). The reaction product was isolated through adsorption on a solid phase of alumina oxide and alumina silicate and was obtained in high purity.
