Management and control of modifier content in preparative SFC solvent cycles

Publikationstyp
Journal Article
Date Issued
2007
Sprache
English
Author(s)
Kaemmerer, Henning  
Brunner, Gerd  
Johannsen, Monika  orcid-logo
Institut
Thermische Verfahrenstechnik V-8  
TORE-URI
http://hdl.handle.net/11420/4770
Journal
The journal of supercritical fluids  
Start Page
204
End Page
213
Citation
Journal of Supercritical Fluids 2 (43): 204-213 (2007)
Publisher DOI
10.1016/j.supflu.2007.02.011
Scopus ID
2-s2.0-34948844095
The objective of this work was to establish a solvent cycle with a possibility for modifier control in a preparative supercritical fluid chromatography simulated moving bed plant (SFC-SMB). Fourier transform infrared (FTIR) spectroscopy and flame ionization detection (FID) have been investigated for measuring alcohol concentrations in supercritical carbon dioxide. The integration of these in-line techniques into a modifier control schema allowed the operation of a closed loop SFC-SMB cycle. The applicability of the developed control concept for usage of 2-propanol in supercritical carbon dioxide has been verified by an experimental test series involving an eight column SFC-SMB plant. Different process variations have been compared in terms of energy and solvent consumption. Hereby, savings of almost all CO2 and 76% modifier could be achieved.
Subjects
Control
Fourier transform infrared spectroscopy (FTIR)
Modifier
Simulated moving bed (SMB)
Solvent cycle
Supercritical fluid chromatography (SFC)
DDC Class
620: Ingenieurwissenschaften