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Structural-functional studies of chorismate synthase and glutamyl-tRNA synthetase from M. tuberculosis
Citation Link: https://doi.org/10.15480/882.421
Other Titles
Struktur-Funktionsstudien der Chorismat Synthase und Glutamyl-tRNA Synthetase aus M. tuberculosis
Publikationstyp
Doctoral Thesis
Date Issued
2008
Sprache
English
Author(s)
Advisor
Referee
Title Granting Institution
Technische Universität Hamburg
Place of Title Granting Institution
Hamburg
Examination Date
2007-11-02
Institut
TORE-DOI
A structural-functional analysis of the enzymes chorismate synthase and glutamyltRNA synthetase from Mycobacterium tuberculosis is presented. Crystal structures of both enzymes were solved using X-ray crystallography and a functional analysis showed how single amino acids strongly influence the enzymatic mechanism on a macroscopic level. The data provides a starting point for the design of novel antimycobacterial compounds.
Subjects
Roentgenkristallografie, Mykobacterium tuberculosis, Shikimat Biosynthese, tRNA Biosynthese, Enzymatische Reaktion
X-ray crystallography, Mycobacterium tuberculosis, Shikimate pathway, tRNA synthesis, enzymatic reaction
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