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Publisher DOI: 10.3390/app11157106
Title: Development and validation of retention models in supercritical fluid chromatography for impregnation process design
Language: English
Authors: Sun, Miaotian 
Ülker, Zeynep 
Chen, Zhixing 
Deeptanshu, Sivaraman 
Johannsen, Monika  
Erkey, Can 
Gurikov, Pavel 
Keywords: aerogels; adsorption; impregnation; supercritical fluid chromatography; retention model
Issue Date: 31-Jul-2021
Publisher: Multidisciplinary Digital Publishing Institute
Source: Applied Sciences 11 (15): 7106 (2021-07-31)
Abstract (english): 
The retention factor is the key quantity for the thermodynamic analysis of the retention mechanism in chromatographic experiments. In this work, we measure retention factors for moderately polar solutes on four silica-based porous matrices as stationary phases by supercritical fluid chromatography. Elution of the solutes is only possible with binary mixtures of supercritical carbon dioxide (sc-CO₂) and modifier (methanol) due to the low polarity of pure sc-CO₂. The addition of modifiers makes the retention mechanism more complex and masks interactions between solute and stationary phase. In this work, we develop and validate several retention models that allow the obtaining of retention factors in modifier-free sc-CO₂. Such models pave the way for quantifying adsorption interactions between polar solutes and non-swellable porous matrices in pure sc-CO₂ based on retention data obtained in sc-CO₂-modifier mixtures. The obtained information will thereby facilitate the understanding and design of impregnation processes, which are often performed in modifier-free conditions.
DOI: 10.15480/882.3714
ISSN: 2076-3417
Journal: Applied Sciences-Basel 
Other Identifiers: doi: 10.3390/app11157106
Institute: Thermische Verfahrenstechnik V-8 
Mehrphasenströmungen V-5 
Entwicklung und Modellierung Neuartiger Nanoporöser Materialien V-EXK2 
Document Type: Article
Project: Publikationsfonds 2021 
More Funding information: Publishing fees supported by Funding Programme Open Access Publishing of Hamburg University of Technology (TUHH).
License: CC BY 4.0 (Attribution) CC BY 4.0 (Attribution)
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