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An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes
Citation Link: https://doi.org/10.15480/882.3842
Publikationstyp
Journal Article
Date Issued
2021-03-02
Sprache
English
Author(s)
Institut
TORE-DOI
Volume
105
Issue
6
Start Page
2225
End Page
2242
Citation
Applied Microbiology and Biotechnology 105 (6): 2225-2242 (2021-03)
Publisher DOI
Scopus ID
PubMed ID
33649923
Publisher
Springer
No matter the scale, stirred tank bioreactors are the most commonly used systems in biotechnological production processes. Single-use and reusable systems are supplied by several manufacturers. The type, size, and number of impellers used in these systems have a significant influence on the characteristics and designs of bioreactors. Depending on the desired application, classic shaft-driven systems, bearing-mounted drives, or stirring elements that levitate freely in the vessel may be employed. In systems with drive shafts, process hygiene requirements also affect the type of seal used. For sensitive processes with high hygienic requirements, magnetic-driven stirring systems, which have been the focus of much research in recent years, are recommended. This review provides the reader with an overview of the most common agitation and seal types implemented in stirred bioreactor systems, highlights their advantages and disadvantages, and explains their possible fields of application. Special attention is paid to the development of magnetically driven agitators, which are widely used in reusable systems and are also becoming more and more important in their single-use counterparts. Key Points • Basic design of the most frequently used bioreactor type: the stirred tank bioreactor • Differences in most common seal types in stirred systems and fields of application • Comprehensive overview of commercially available bioreactor seal types • Increased use of magnetically driven agitation systems in single-use bioreactors
Subjects
Application trends
Bioreactor agitation
Hygienic requirements
Lip seal
Magnetic coupling
Mechanical sealing
DDC Class
600: Technik
More Funding Information
Open Access funding provided by ZHAWZürcher Hochschule für Angewandte Wissenschaften.
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