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Magnetic particle imaging for assessment of cerebral perfusion and ischemia
Citation Link: https://doi.org/10.15480/882.4132
Publikationstyp
Review Article
Date Issued
2022-01
Sprache
English
Institut
TORE-DOI
Volume
14
Issue
1
Article Number
e1757
Citation
Wiley Interdisciplinary Reviews: WIREs. Nanomedicine and Nanobiotechnology 14 (1): e1757 (2021-02)
Publisher DOI
Scopus ID
Publisher
Wiley-Blackwell
Stroke is one of the leading worldwide causes of death and sustained disability. Rapid and accurate assessment of cerebral perfusion is essential to diagnose and successfully treat stroke patients. Magnetic particle imaging (MPI) is a new technology with the potential to overcome some limitations of established imaging modalities. It is an innovative and radiation-free imaging technique with high sensitivity, specificity, and superior temporal resolution. MPI enables imaging and diagnosis of stroke and other neurological pathologies such as hemorrhage, tumors, and inflammatory processes. MPI scanners also offer the potential for targeted therapies of these diseases. Due to lower field requirements, MPI scanners can be designed as resistive magnets and employed as mobile devices for bedside imaging. With these advantages, MPI could accelerate and improve the diagnosis and treatment of neurological disorders. This review provides a basic introduction to MPI, discusses its current use for stroke imaging, and addresses future applications, including the potential for clinical implementation. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease.
Subjects
imaging
magnetic particle imaging
stroke
theranostics
DDC Class
530: Physik
570: Biowissenschaften, Biologie
600: Technik
610: Medizin
620: Ingenieurwissenschaften
Funding Organisations
Hermann und Lily Schilling Stiftung
More Funding Information
This work was supported by the “Forschungszentrums Medizintechnik Hamburg” (FMTHH) by the Hertie-Stiftung
(Hertie Academy of Clinical Neuroscience), the German Research Foundation (DFG; grant numbers: GR 5287/2–1, KN 1108/7–1, DFG FOR 2879 [project LU 1924/1–1 and MA 4375/6–1]), and the “Hermann und Lily Schilling Stiftung”.
This work was also supported by the BMBF under the frame of EuroNanoMed III (grant number: 13XP5060B,
“Magnetize”).
(Hertie Academy of Clinical Neuroscience), the German Research Foundation (DFG; grant numbers: GR 5287/2–1, KN 1108/7–1, DFG FOR 2879 [project LU 1924/1–1 and MA 4375/6–1]), and the “Hermann und Lily Schilling Stiftung”.
This work was also supported by the BMBF under the frame of EuroNanoMed III (grant number: 13XP5060B,
“Magnetize”).
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WIREs Nanomed Nanobiotechnol - 2021 - Ludewig - Magnetic particle imaging for assessment of cerebral perfusion and ischemia.pdf
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