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  4. MPI tracer interactions and their effect on signal stability
 
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MPI tracer interactions and their effect on signal stability

Citation Link: https://doi.org/10.15480/882.4408
Publikationstyp
Journal Article
Date Issued
2022-03-21
Sprache
English
Author(s)
Moor, Lorena  
Scheibler, Subas  
Gerken, Lukas  
Scheffler, Konrad  
Thieben, Florian  orcid-logo
Knopp, Tobias  
Herrmann, Inge Katrin  
Starsich, Fabian  
Institut
Biomedizinische Bildgebung E-5  
TORE-DOI
10.15480/882.4408
TORE-URI
http://hdl.handle.net/11420/12575
Journal
International journal on magnetic particle imaging  
Volume
8
Issue
1. Suppl 1
Article Number
2203056
Citation
International Journal on Magnetic Particle Imaging 8 (1, Suppl 1): 2203056 (2022)
Publisher DOI
10.18416/ijmpi.2022.2203056
Scopus ID
2-s2.0-85128275601
Nanoparticles tend to agglomerate following their in vivo or in vitro application. This leads to particle interaction and, for magnetic particle imaging (MPI) tracers, to magnetic coupling phenomena. Here, we investigate these effects and their influence on magnetic particle spectroscopy (MPS) and MPI signal stability. Highly magnetic flame-made Zn-ferrites with controlled interparticle distance are suggested as a stable MPI tracer system. Due to their pre-aggregated morphology, additional agglomeration does not substantially alter their magnetic response. This is in strong contrast to frequently investigated polymer-coated iron oxide nanoparticles, which show a massive MPS signal loss in a biologically relevant dispersion medium compared to water. This effect is also shown during MPI and renders these tracers inapplicable to further applications. Our flame-made Zn-ferrites, on the other hand, show sufficient signal stability, which allows their detailed quantification via MPI.
DDC Class
004: Informatik
610: Medizin
More Funding Information
We thank the Swiss National Science Foundation for generous funding through the Eccellenza (181290) and the Scientific Exchange scheme
(IZSEZ0_205894).
Publication version
publishedVersion
Lizenz
https://creativecommons.org/licenses/by/4.0/
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