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  4. Characterization of the Synomag®-D-PEG-OMe nanoparticles for the encapsulation in human and murine red blood cells
 
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Characterization of the Synomag®-D-PEG-OMe nanoparticles for the encapsulation in human and murine red blood cells

Citation Link: https://doi.org/10.15480/882.4417
Publikationstyp
Journal Article
Date Issued
2022-03-21
Sprache
English
Author(s)
Antonelli, Antonella  
Scarpa, Emanuele Salvatore  
Di Corato, Riccardo  
Thieben, Florian  orcid-logo
Grüttner, Cordula  
Knopp, Tobias  
Magnani, Mauro  
Institut
Biomedizinische Bildgebung E-5  
TORE-DOI
10.15480/882.4417
TORE-URI
http://hdl.handle.net/11420/12578
Journal
International journal on magnetic particle imaging  
Volume
8
Issue
1, Suppl 1
Article Number
2203038
Citation
International Journal on Magnetic Particle Imaging 8 (1, Suppl 1): 2203038 (2022)
Publisher DOI
10.18416/ijmpi.2022.2203038
Scopus ID
2-s2.0-85128258444
Publisher
Infinite Science Publishing
It was shown that the encapsulation of SPIO-based contrast agents in the red blood cells (RBCs) increases the circulation time in blood of these nanomaterials. Not all iron oxide particles are eligible for the entrapment into RBCs, depending on several factors and synthesis protocol. We have recently identified some type of nanoparticles that can be loaded with our method into RBCs to produce biocompatible SPIO-RBCs carriers that could be used as new intravascular tracers for biomedical applications, such as Magnetic Particle Imaging (MPI). Here, we report the first in vitro results obtained by using the Synomag®-D-PEG-OMe nanoparticles with both human and murine RBCs. MPS analysis showed that human Synomag®-D-PEG-OMe-loaded RBCs produced a signal that is weaker respect to the remarkable signal obtained with ferucarbotran loaded-RBCs prepared at the same condition, but it is to be noted that the encapsulation efficiency of Synomag®-D-PEG-OMe into cells is lower compared to ferucarbotran nanoparticles.
DDC Class
004: Informatik
610: Medizin
Funding(s)
MAGnetic Particle Imaging for the Treatment and Imaging of Stroke  
Funding Organisations
Bundesministerium für Bildung und Forschung (BMBF)  
Publication version
publishedVersion
Lizenz
https://creativecommons.org/licenses/by/4.0/
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