Publisher DOI: 10.18416/ijmpi.2022.2203038
Title: Characterization of the Synomag®-D-PEG-OMe nanoparticles for the encapsulation in human and murine red blood cells
Language: English
Authors: Antonelli, Antonella 
Scarpa, Emanuele Salvatore 
Di Corato, R. 
Thieben, Florian  
Gruettner, Cordula 
Knopp, Tobias 
Magnani, Mauro 
Issue Date: 2022
Source: International Journal on Magnetic Particle Imaging 8 (1) : 2203038 (2022)
Journal: International journal on magnetic particle imaging 
Abstract (english): 
It was shown that the encapsulation of SPIO-based contrast agents in the red blood cells (RBCs) increases the circulation time in blood of these nanomaterials. Not all iron oxide particles are eligible for the entrapment into RBCs, depending on several factors and synthesis protocol. We have recently identified some type of nanoparticles that can be loaded with our method into RBCs to produce biocompatible SPIO-RBCs carriers that could be used as new intravascular tracers for biomedical applications, such as Magnetic Particle Imaging (MPI). Here, we report the first in vitro results obtained by using the Synomag®-D-PEG-OMe nanoparticles with both human and murine RBCs. MPS analysis showed that human Synomag®-D-PEG-OMe-loaded RBCs produced a signal that is weaker respect to the remarkable signal obtained with ferucarbotran loaded-RBCs prepared at the same condition, but it is to be noted that the encapsulation efficiency of Synomag®-D-PEG-OMe into cells is lower compared to ferucarbotran nanoparticles.
ISSN: 2365-9033
Institute: Biomedizinische Bildgebung E-5 
Document Type: Article
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