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  4. Understanding and Engineering Glycine Cleavage System and Related Metabolic Pathways for C1-Based Biosynthesis
 
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Understanding and Engineering Glycine Cleavage System and Related Metabolic Pathways for C1-Based Biosynthesis

Publikationstyp
Journal Article
Date Issued
2022
Sprache
English
Author(s)
Ren, Jie  
Wang, Wei  
Nie, Jinglei  
Yuan, Wenqiao  
Zeng, An-Ping  orcid-logo
Institut
Bioprozess- und Biosystemtechnik V-1  
TORE-URI
http://hdl.handle.net/11420/12873
Journal
Advances in biochemical engineering, biotechnology  
Volume
180
Start Page
273
End Page
298
Citation
Advances in Biochemical Engineering/Biotechnology 180: 273-298 (2022)
Publisher DOI
10.1007/10_2021_186
Scopus ID
2-s2.0-85131221645
PubMed ID
35294558
The glycine cleavage system (GCS) is a fundamental component of life, widely existing in microbes, plants, animals, and humans. A better understanding of the functionality and working mechanisms, and the engineering of the GCS have both scientific and practical impacts, which may lead to new knowledge and findings in life sciences, improved biomass production and human/animal health, efficient biosynthesis of chemicals, effective carbon fixation and global climate change mitigation. In this chapter, the GCS is first discussed in the context of the reductive glycine pathway (rGlyP), a recently proposed and appealing assimilation pathway of CO2 and formate, and its implementation and optimization in microorganisms for formatotrophic growth. Then, the present knowledge about the components, reactions, and working mechanisms of the GCS and related enzymes is reviewed. Particular emphasis is also placed on the conformational and structural features of the GCS proteins, especially the different forms of lipoylated H protein and its lipoylation by lipoate protein ligase (LplA). Subsequently, existing analytic methods for the components and reactions of the GCS and recent advances in quantitatively understanding and purposefully engineering the GCS are presented. Finally, perspectives of current state of the art in the GCS research are given and future research needs are highlighted.
Subjects
Aminomethyl-transferase
C1 assimilation
Dihydrolipoyl dehydrogenase
Glycine cleavage system
Glycine decarboxylase
H protein
L protein
P protein
Reductive glycine pathway
T protein
DDC Class
620: Ingenieurwissenschaften
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