Please use this identifier to cite or link to this item: https://doi.org/10.15480/882.4669
Publisher DOI: 10.3390/pr10102137
Title: Concept of an enzymatic reactive extraction centrifuge
Language: English
Authors: Meyer, Francesca 
Gasimov, Nijat 
Bubenheim, Paul  
Waluga, Thomas 
Keywords: process integration; biocatalysis; hybrid process; multi-enzyme cascade; process intensification
Issue Date: 20-Oct-2022
Publisher: Multidisciplinary Digital Publishing Institute
Source: Processes 10 (10): 2137 (2022)
Abstract (english): 
Biocatalytic processes often provide an ecological alternative to many chemical processes. However, further improvements in terms of the economic efficiency are required. In order to achieve that, the concept of process integration is a promising option. Applying this within a biocatalytic process, a highly integrated apparatus working as a reactive extraction centrifuge was developed and operated. For this purpose, a commercially available extraction centrifuge was modified to implement a biocatalytic reaction. The novel apparatus was used within a multi-enzyme cascade for the production of a natural flavor and fragrance, namely cinnamic ester. The characterization of the reactive extraction centrifuge and the suitable operation conditions for the inlet streams and the rotational speed for a stable operation were determined. Furthermore, different initial substrate concentrations were applied to prove the reaction. The results provide a successful proof of concept for the novel reactive extraction centrifuge.
URI: http://hdl.handle.net/11420/13841
DOI: 10.15480/882.4669
ISSN: 2227-9717
Journal: Processes 
Other Identifiers: doi: 10.3390/pr10102137
Institute: Systemverfahrenstechnik V-4 
Technische Biokatalyse V-6 
Document Type: Article
Project: Multienzymkaskade im 2-Phasensystem 
Open-Access-Publikationskosten / 2022-2024 / Technische Universität Hamburg (TUHH) 
Funded by: Deutsche Forschungsgemeinschaft (DFG) 
License: CC BY 4.0 (Attribution) CC BY 4.0 (Attribution)
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