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Publisher DOI: 10.1002/cite.202200157
Title: Influence of process parameters and particle size distribution on mechanical properties of tablets
Language: English
Authors: Ait Ouazzou, Amine 
Harshe, Yogesh M. 
Meunier, Vincent 
Finke, Jan H. 
Heinrich, Stefan 
Keywords: Diametral crushing; Maltodextrin; Porosity; Tableting; X-ray tomography
Issue Date: 20-Dec-2022
Publisher: Wiley-VCH Verl.
Source: Chemie-Ingenieur-Technik 95 (1-2): 168-177 (2023)
Abstract (english): 
The influence of the particle size distribution of maltodextrin powders with a dextrose equivalent level of 29 as well as two tableting process variables, namely the compression pressure and the dwell time, on the tensile strength, porosity, and pore size distribution of the final tablet was studied. The mechanical strength and porosity of the tablets are assessed in relation to the powder and process parameters. Regarding the process parameter, it was show that the compaction pressure clearly has a more pronounced influence on the tablet porosity and mechanical strength compared to the influence of the dwell time in the range of the study. As a result, the study offers a better understanding of how the properties of a tablet are influenced by the inter-correlation of powder characteristics and tableting parameters. Therefore, the shelf-life studies and tablet downstream processing as well as drug product development will benefit greatly from this work.
DOI: 10.15480/882.4894
ISSN: 1522-2640
Journal: Chemie - Ingenieur - Technik 
Institute: Feststoffverfahrenstechnik und Partikeltechnologie V-3 
Document Type: Article
Project: Projekt DEAL 
European Union’s Horizon 
More Funding information: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sk=lodowska-Curie grant agreement No 955661.
License: CC BY 4.0 (Attribution) CC BY 4.0 (Attribution)
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