Influence of process parameters and particle size distribution on mechanical properties of tablets

Enthalten in
Chemie - Ingenieur - Technik 
Volume
95
Issue
1-2
Start Page
168
End Page
177
Citation
Chemie-Ingenieur-Technik 95 (1-2): 168-177 (2023)
Publisher DOI
10.1002/cite.202200157
Scopus ID
2-s2.0-85144231941
Publisher
Wiley-VCH Verl.
The influence of the particle size distribution of maltodextrin powders with a dextrose equivalent level of 29 as well as two tableting process variables, namely the compression pressure and the dwell time, on the tensile strength, porosity, and pore size distribution of the final tablet was studied. The mechanical strength and porosity of the tablets are assessed in relation to the powder and process parameters. Regarding the process parameter, it was show that the compaction pressure clearly has a more pronounced influence on the tablet porosity and mechanical strength compared to the influence of the dwell time in the range of the study. As a result, the study offers a better understanding of how the properties of a tablet are influenced by the inter-correlation of powder characteristics and tableting parameters. Therefore, the shelf-life studies and tablet downstream processing as well as drug product development will benefit greatly from this work.
Schlagworte
Diametral crushing
Maltodextrin
Porosity
Tableting
X-ray tomography
DDC Class
600: Technik
620: Ingenieurwissenschaften
Projekt(e)
Projekt DEAL 
Training in Upscaling particle Systems: Advancing Industry across Length-scales 
More Funding Information
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sk=lodowska-Curie grant agreement No 955661.