Influence of process parameters and particle size distribution on mechanical properties of tablets

The influence of the particle size distribution of maltodextrin powders with a dextrose equivalent level of 29 as well as two tableting process variables, namely the compression pressure and the dwell time, on the tensile strength, porosity, and pore size distribution of the final tablet was studied. The mechanical strength and porosity of the tablets are assessed in relation to the powder and process parameters. Regarding the process parameter, it was show that the compaction pressure clearly has a more pronounced influence on the tablet porosity and mechanical strength compared to the influence of the dwell time in the range of the study. As a result, the study offers a better understanding of how the properties of a tablet are influenced by the inter-correlation of powder characteristics and tableting parameters. Therefore, the shelf-life studies and tablet downstream processing as well as drug product development will benefit greatly from this work.

Subjects

Diametral crushing

Maltodextrin

Porosity

Tableting

X-ray tomography

DDC Class

600: Technik

620: Ingenieurwissenschaften

Funding(s)

Projekt DEAL

Training in Upscaling particle Systems: Advancing Industry across Length-scales

More Funding Information

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sk=lodowska-Curie grant agreement No 955661.

Publication version

publishedVersion

Lizenz

https://creativecommons.org/licenses/by/4.0/

Name

Chemie Ingenieur Technik - 2022 - Ouazzou - Influence of Process Parameters and Particle Size Distribution on Mechanical.pdf

Size

1.05 MB

Format

Adobe PDF

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Influence of process parameters and particle size distribution on mechanical properties of tablets