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Substrates and oxygen dependent citric acid production by Yarrowia lipolytica: insights through transcriptome and fluxome analyses
Citation Link: https://doi.org/10.15480/882.1496
Publikationstyp
Journal Article
Date Issued
2017-05-08
Sprache
English
Institut
TORE-DOI
Journal
Volume
16
Issue
1
Start Page
78
Citation
Microbial cell factories 1 (16): 78- (2017-05-08)
Publisher DOI
Scopus ID
Publisher
BioMed Central
Unlike the well-studied backer yeast where catabolite repression represents a burden for mixed substrate fermentation, Yarrowia lipolytica, an oleaginous yeast, is recognized for its potential to produce single cell oils and citric acid from different feedstocks. These versatilities of Y. lipolytica with regards to substrate utilization make it an attractive host for biorefinery application. However, to develop a commercial process for the production of citric acid by Y. lipolytica, it is necessary to better understand the primary metabolism and its regulation, especially for growth on mixed substrate.
Subjects
Citric acid
Dual substrate
Glyoxylate cycle
Oleaginous yeast
Pentose phosphate pathway
Citrates
Citric Acid
Culture Media
Fermentation
Gene Expression Profiling
Glucose
Glycerol
Glyoxylates
Metabolic Flux Analysis
Oxygen
Pentose Phosphate Pathway
Yarrowia
DDC Class
540: Chemie
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