Substrates and oxygen dependent citric acid production by Yarrowia lipolytica: insights through transcriptome and fluxome analyses

Sabra, Wael; Bommareddy, Rajesh Reddy; Maheshwari, Garima; Papanikolaou, Seraphim; Zeng, An-Ping

doi:10.1186/s12934-017-0690-0

Please use this identifier to cite or link to this item: https://doi.org/10.15480/882.1496

Publisher DOI:	10.1186/s12934-017-0690-0
Title:	Substrates and oxygen dependent citric acid production by Yarrowia lipolytica: insights through transcriptome and fluxome analyses
Language:	English
Authors:	Sabra, Wael Bommareddy, Rajesh Reddy Maheshwari, Garima Papanikolaou, Seraphim Zeng, An-Ping
Keywords:	Citric acid;Dual substrate;Glyoxylate cycle;Oleaginous yeast;Pentose phosphate pathway;Citrates;Citric Acid;Culture Media;Fermentation;Gene Expression Profiling;Glucose;Glycerol;Glyoxylates;Metabolic Flux Analysis;Oxygen;Pentose Phosphate Pathway;Yarrowia
Issue Date:	8-May-2017
Publisher:	BioMed Central
Source:	Microbial cell factories 1 (16): 78- (2017-05-08)
Journal or Series Name:	Microbial cell factories
Abstract (english):	Unlike the well-studied backer yeast where catabolite repression represents a burden for mixed substrate fermentation, Yarrowia lipolytica, an oleaginous yeast, is recognized for its potential to produce single cell oils and citric acid from different feedstocks. These versatilities of Y. lipolytica with regards to substrate utilization make it an attractive host for biorefinery application. However, to develop a commercial process for the production of citric acid by Y. lipolytica, it is necessary to better understand the primary metabolism and its regulation, especially for growth on mixed substrate.
URI:	http://tubdok.tub.tuhh.de/handle/11420/1499
DOI:	10.15480/882.1496
ISSN:	1475-2859
Institute:	Bioprozess- und Biosystemtechnik V-1
Type:	(wissenschaftlicher) Artikel
Project:	Open Access Publizieren 2016 - 2017 / Technische Universität Hamburg-Harburg
License:	CC BY 4.0 (Attribution)
Appears in Collections:	Publications with fulltext