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  4. Using negative bolus in dynamic MPI
 
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Using negative bolus in dynamic MPI

Citation Link: https://doi.org/10.15480/882.5084
Publikationstyp
Journal Article
Date Issued
2023-03-19
Sprache
English
Author(s)
Mohn, Fabian  orcid-logo
Exner, Miriam  
Szwargulski, Patryk  
Möddel, Martin  orcid-logo
Knopp, Tobias  
Gräser, Matthias 
Institut
Biomedizinische Bildgebung E-5  
TORE-DOI
10.15480/882.5084
TORE-URI
http://hdl.handle.net/11420/15209
Journal
International journal on magnetic particle imaging  
Volume
9
Issue
1
Article Number
2303022
Citation
International Journal on Magnetic Particle Imaging 9 (1): 2303022 (2023)
Publisher DOI
10.18416/IJMPI.2023.2303022
Scopus ID
2-s2.0-85151487659
Publisher
Infinite Science Publishing
In Magnetic Particle Imaging, the spatial distribution of a tracer is measured and depicted with a concentration dependent signal intensity for any location that contains particles, whereas surrounding tissue does not provide any signal. After tracer injection, the signal over time (positive contrast) can be utilized as a transient response to calculate dynamic diagnostic parameters like perfusion parameter maps. In this work, a bolus of physiological saline solution without any particles (negative contrast) is proposed, where the remaining steady state concentration contributes to the image contrast. This opens up the possibility to stretch the total monitoring time of a patient by utilizing a positive-negative contrast sequence, while keeping the total iron dose constant in the subject. Resulting time responses show that normalized signals from positive and negative boli are concurrent in the phantom experiments, indicating identical diagnostic parameters for in-vivo use.
DDC Class
600: Technik
620: Ingenieurwissenschaften
Publication version
publishedVersion
Lizenz
https://creativecommons.org/licenses/by/4.0/
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