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Publisher DOI: 10.1177/0954411914558654
Title: The effect of in situ/in vitro three-dimensional quantitative computed tomography image voxel size on the finite element model of human vertebral cancellous bone
Language: English
Authors: Lu, Yongtao 
Engelke, Klaus 
Glüer, Claus Christian 
Morlock, Michael 
Huber, Gerd 
Keywords: Quantitative computed tomography image;finite element;in situ;in vitro;vertebra;voxel size;Absorptiometry, Photon;Aged;Aged, 80 and over;Bone Density;Compressive Strength;Computer Simulation;Elastic Modulus;Female;Finite Element Analysis;Humans;Imaging, Three-Dimensional;Middle Aged;Radiographic Image Interpretation, Computer-Assisted;Reproducibility of Results;Sensitivity and Specificity;Thoracic Vertebrae;Tomography, X-Ray Computed;Models, Biological
Issue Date: 2014
Source: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine 11 (228): 1208-13-1213 (2014-11)
Journal or Series Name: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine 
Abstract (english): Quantitative computed tomography-based finite element modeling technique is a promising clinical tool for the prediction of bone strength. However, quantitative computed tomography-based finite element models were created from image datasets with different image voxel sizes. The aim of this study was to investigate whether there is an influence of image voxel size on the finite element models. In all 12 thoracolumbar vertebrae were scanned prior to autopsy (in situ) using two different quantitative computed tomography scan protocols, which resulted in image datasets with two different voxel sizes (0.29 × 0.29 × 1.3 mm(3) vs 0.18 × 0.18 × 0.6 mm(3)). Eight of them were scanned after autopsy (in vitro) and the datasets were reconstructed with two voxel sizes (0.32 × 0.32 × 0.6 mm(3) vs. 0.18 × 0.18 × 0.3 mm(3)). Finite element models with cuboid volume of interest extracted from the vertebral cancellous part were created and inhomogeneous bilinear bone properties were defined. Axial compression was simulated. No effect of voxel size was detected on the apparent bone mineral density for both the in situ and in vitro cases. However, the apparent modulus and yield strength showed significant differences in the two voxel size group pairs (in situ and in vitro). In conclusion, the image voxel size may have to be considered when the finite element voxel modeling technique is used in clinical applications.
DOI: 10.15480/882.1586
ISSN: 0954-4119
Institute: Biomechanik M-3 
Type: (wissenschaftlicher) Artikel
Permission Note: Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
License: In Copyright In Copyright
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