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https://doi.org/10.15480/882.1666

Title: | Process development for the simultaneous microbial production of n-butanol and 1,3-propanediol | Language: | English | Authors: | Prescher, Christin | Keywords: | Prozessentwicklung; Bioraffinerie; N-Butanol; 1,3-Propandiol; Clostridium pasteurianum | Issue Date: | 2018 | Examination Date: | 23-Feb-2018 | Abstract (german): | Diese Arbeit umfasst die Entwicklung eines biotechnologischen Prozesses, zur Herstellung von n-Butanol und 1,3-Propandiol mit Clostridium pasteurianum DSMZ 525, unter der Verwendung von nachwachsenden Rohstoffen. Dabei wurde der Einfluss von verschiedenen Substraten, Eisenverfügbarkeit im Medium, redox-aktiven Substanzen und der Einsatz von Elektrobioreaktoren untersucht. Des Weiteren wurde der Effekt von in situ Gasstripping, zur Abtrennung des inhibierend wirkenden n-Butanols, analysiert und der Prozess optimiert. Unter den besten Kultivierungsbedingungen konnten 39 g/L n-Butanol und 53 g /L 1,3-PDO hergestellt werden. |
Abstract (english): | This thesis comprises the development of a biotechnological process for the simultaneous production of n-butanol and 1,3-propanediol with Clostridium pasteurianum DSMZ 525, growing on substrates from renewable resources. The influence of carbon sources with different reductive states, iron availability in the medium, redox active mediators and electro-bioreactors on metabolism and productivity were analyzed. For the recovery of inhibiting n-butanol, in situ gas stripping was implemented in the fermentation process and further optimized. Under the best conditions C. pasteurianum DSMZ 525 produced simultaneously 39 g/L BuOH and 53 g/L 1,3-PDO. |
URI: | http://tubdok.tub.tuhh.de/handle/11420/1669 | DOI: | 10.15480/882.1666 | Institute: | Bioprozess- und Biosystemtechnik V-1 | Document Type: | Thesis | Thesis Type: | Doctoral Thesis | Advisor: | Zeng, An-Ping ![]() |
Referee: | Smirnova, Irina ![]() |
Project: | EUROBIOREF | License: | ![]() |
Appears in Collections: | Publications with fulltext |
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File | Description | Size | Format | |
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Dissertation - C. Prescher TubDok.pdf | PROCESS DEVELOPMENT FOR THE SIMULTANEOUS MICROBIAL PRODUCTION OF n-BUTANOL AND 1,3-PROPANEDIO ------ Dissertation Christin Prescher 2018L | 3,17 MB | Adobe PDF | View/Open![]() |
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