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Publisher DOI: 10.1186/s12934-016-0497-4
Title: Fermentation of mixed substrates by Clostridium pasteurianum and its physiological, metabolic and proteomic characterizations
Language: English
Authors: Sabra, Wael 
Wang, Wei 
Surandram, Sruthi 
Prescher, Christin 
Zeng, An-Ping 
Keywords: 1,3-propanediol;Butanol;Mixed substrate fermentation;Oxaloacetate;Pyruvate decarboxylation;1-Butanol;Bacterial Proteins;Clostridium;Fermentation;Glucose;Propylene Glycols;Proteomics
Issue Date: 21-Jun-2016
Publisher: BioMed Central
Source: Microbial cell factories 1 (15): 114- (2016-06-21)
Journal or Series Name: Microbial cell factories 
Abstract (english): Clostridium pasteurianum is becoming increasingly attractive for the production of chemicals and fuels such as n-butanol and 1,3-propanediol. Previously we have shown that dual substrate fermentation using glucose and glycerol enhanced the cell growth and butanol production significantly. Although C. pasteurianum can grow efficiently with either glucose or glycerol alone, under certain conditions, glucose limitation in the mixed substrate fermentation leads to growth cessation. To understand this phenomenon and for process optimization, fermentation experiments were performed in the presence of excess glycerol but with varied initial concentrations of glucose which were followed by physiological, metabolic and proteomic analyses.
DOI: 10.15480/882.1711
ISSN: 1475-2859
Institute: Bioprozess- und Biosystemtechnik V-1 
Type: (wissenschaftlicher) Artikel
Appears in Collections:Publications (tub.dok)

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