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Metabolic engineering von Clostridium pasteurianum zur Optimierung der Biobutanolproduktion
Citation Link: https://doi.org/10.15480/882.1887
Publikationstyp
Doctoral Thesis
Date Issued
2018
Sprache
German
Author(s)
Advisor
Referee
Title Granting Institution
Technische Universität Hamburg
Place of Title Granting Institution
Hamburg
Examination Date
2018-11-09
Institut
TORE-DOI
Clostridium pasteurianum is of great industrial interest regarding its substrate utilization and product spectrum. In this study, methods for metabolic engineering of C. pasteurianum, especially transformation and gene deletion, were analyzed and optimized. Optimized strains were generated by overexpression of pyruvate carboxylase and glycerol dehydratase deletion. Butanol production was selectively increased. Furthermore, our results indicate a novel mechanism of redox regulation in C. pasteurianum.
Subjects
Biobutanolproduktion
Metabolic engineering
Clostridium pasteurianum
DDC Class
500: Naturwissenschaften
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Thesis_R_Schmitz.pdf
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2.92 MB
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