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Publisher DOI: 10.2174/1874070701610010001
Title: Multi-fixed-bed bioreactor system applied for bioprocess development of immobilized lactic acid bacteria
Language: English
Authors: Faschian, Rebecca 
De, Sonakshi 
Pörtner, Ralf  
Keywords: Cell density;continuous cultivation;dilution rate;experimental error;fixed-bed;lactic acid bacteria;metabolic activity;process development;scale-down
Issue Date: 19-Feb-2016
Publisher: Bentham Open
Source: Open Biotechnology Journal 1 (10): 1-9 (2016-02-01)
Journal or Series Name: The open biotechnology journal 
Abstract (english): The multi-fixed-bed bioreactor “Multiferm” provides a downscaled system for the development of fixed-bed processes with immobilized microorganisms or cells. It consists of twelve single fixed-bed units that can be operated independently. Different bacterial strains, carriers used for immobilization, media or flow rates can be studied in one compact experimental set-up. Experiments can be run in parallel to allow for determination of experimental errors. In these studies several continuous cultivations were carried out with Lactobacillus delbrueckii ssp. bulgaricus using different dilution rates and culture durations as proof-ofconcept for the Multiferm. Parameters relevant for process design such as reproducibility of simultaneously performed cultures, optimal dilution rate and long-term performance were determined by means of volume specific lactate and biomass productivity. First indications on a reduced growth rate of the cells due to immobilization were found.
DOI: 10.15480/882.1998
ISSN: 1874-0707
Institute: Bioprozess- und Biosystemtechnik V-1 
Type: (wissenschaftlicher) Artikel
License: CC BY-NC 4.0 (Attribution-NonCommercial) CC BY-NC 4.0 (Attribution-NonCommercial)
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