Dieses Dokument steht unter einer CreativeCommons Lizenz by-nc/4.0
Verlagslink DOI: 10.2174/1874070701610010001
Titel: Multi-fixed-bed bioreactor system applied for bioprocess development of immobilized lactic acid bacteria
Sprache: English
Autor/Autorin: Faschian, Rebecca 
De, Sonakshi 
Pörtner, Ralf 
Schlagwörter: Cell density;continuous cultivation;dilution rate;experimental error;fixed-bed;lactic acid bacteria;metabolic activity;process development;scale-down
Erscheinungsdatum: 19-Feb-2016
Verlag: Bentham Open
Quellenangabe: Open Biotechnology Journal 1 (10): 1-9 (2016-02-01)
Zeitschrift oder Schriftenreihe: The open biotechnology journal 
Zusammenfassung (englisch): The multi-fixed-bed bioreactor “Multiferm” provides a downscaled system for the development of fixed-bed processes with immobilized microorganisms or cells. It consists of twelve single fixed-bed units that can be operated independently. Different bacterial strains, carriers used for immobilization, media or flow rates can be studied in one compact experimental set-up. Experiments can be run in parallel to allow for determination of experimental errors. In these studies several continuous cultivations were carried out with Lactobacillus delbrueckii ssp. bulgaricus using different dilution rates and culture durations as proof-ofconcept for the Multiferm. Parameters relevant for process design such as reproducibility of simultaneously performed cultures, optimal dilution rate and long-term performance were determined by means of volume specific lactate and biomass productivity. First indications on a reduced growth rate of the cells due to immobilization were found.
URI: https://tubdok.tub.tuhh.de/handle/11420/2001
DOI: 10.15480/882.1998
ISSN: 1874-0707
Institut: Bioprozess- und Biosystemtechnik V-1 
Dokumenttyp: (wissenschaftlicher) Artikel
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