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Publisher DOI: 10.1530/EC-18-0456
Title: Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties
Language: English
Authors: Picke, Ann-Kristin 
Campbell, Graeme Michael 
Napoli, Nicola 
Hofbauer, Lorenz C. 
Rauner, Martina 
Keywords: bone;diabetes
Issue Date: Mar-2019
Source: Endocrine Connections 3 (8): R55-R70 (2019-01-03)
Journal or Series Name: Endocrine Connections 
Abstract (english): The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide, especially as a result of our aging society, high caloric intake and sedentary lifestyle. Besides the well-known complications of T2DM on the cardiovascular system, the eyes, kidneys and nerves, bone strength is also impaired in diabetic patients. Patients with T2DM have a 40–70% increased risk for fractures, despite having a normal to increased bone mineral density, suggesting that other factors besides bone quantity must account for increased bone fragility. This review summarizes the current knowledge on the complex effects of T2DM on bone including effects on bone cells, bone mat erial properties and other endocrine systems that subsequently affect bone, discusses the effects of T2DM medications on bone and concludes with a model identifying factors that may contribute to poor bone quality and increased bone fragility in T2DM. © 2019 The authors Published by Bioscientifica Ltd.
DOI: 10.15480/882.2208
ISSN: 2049-3614
Institute: Biomechanik M-3 
Type: (wissenschaftlicher) Artikel
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