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  4. Model-based tools for optimal experiments in bioprocess engineering
 
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Model-based tools for optimal experiments in bioprocess engineering

Publikationstyp
Journal Article
Date Issued
2018-12
Sprache
English
Author(s)
Abt, Vinzenz  
Barz, Tilman  
Cruz, Nicolay  
Herwig, Christoph  
Kroll, Paul  
Möller, Johannes  
Pörtner, Ralf  orcid-logo
Schenkendorf, René  
Institut
Bioprozess- und Biosystemtechnik V-1  
TORE-URI
http://hdl.handle.net/11420/2392
Journal
Current opinion in chemical engineering  
Volume
22
Start Page
244
End Page
252
Citation
Current Opinion in Chemical Engineering (22): 244-252 (2018-12)
Publisher DOI
10.1016/j.coche.2018.11.007
Scopus ID
2-s2.0-85058025537
Currently applied methods for characterization and optimization of bio-pharmaceutical processes are still strongly empirical. This often involves Design of Experiment (DoE) methods that require a large number of time-consuming experiments and can hardly fulfill the requirements of ‘Quality by Design’ (QbD). Linking mathematical models with experimental methods is seen as an efficient strategy that significantly reduces development time and costs. Furthermore, if combined with advanced Process Analytical Technology (PAT), higher automation and more efficient workflows can be established along the product lifecycle. This contribution presents the state of the art of model-based tools for experimental design and gives an outlook on future trends in the field of bio-process engineering.
Funding(s)
IBÖ-04: mDoE-Toolbox - Software zur modellgestützten Optimierung biotechnologischer Prozesse  
IBÖM04:mDoE-Toolbox2-Neue mDoE Software-Toolbox zur modellgestützten Optimierung biotechnologischer Prozesse  
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