Publisher DOI: 10.1002/cite.201700054
Title: Continuous Countercurrent Extractive Biocatalysis in Aqueous Surfactant Two-Phase Systems
Language: English
Authors: Ritter, Eric 
Smirnova, Irina 
Issue Date: Mar-2018
Source: Chemie-Ingenieur-Technik 3 (90): 348-357 (2018-03)
Journal or Series Name: Chemie - Ingenieur - Technik 
Abstract (english): To evaluate the possibility of performing extractive biocatalysis in continuous mode, the hydrolysis of penicillin G in a micellar solution containing the nonionic surfactant Tergitol NP-7 was chosen as model system. While the product phenylacetic acid distributes into the micellar phase, 6-aminopenicillanic acid moves preferably into the aqueous phase. The yield in the continuous multi-step process was higher in comparison to equivalent batch systems. Overall, the results demonstrate the suitability of aqueous surfactant two-phase systems for continuous biocatalytic reactive extraction processes.
ISSN: 0009-286X
Institute: Thermische Verfahrenstechnik V-8 
Type: (wissenschaftlicher) Artikel
Funded by: DFG Project SM 82/14-1
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