Publisher DOI: 10.1016/j.supflu.2017.03.005
Title: Amorphization of drugs by adsorptive precipitation from supercritical solutions: A review
Authors: Gurikov, Pavel 
Smirnova, Irina  
Issue Date: Feb-2018
Source: Journal of Supercritical Fluids (132): 105-125 (2018-02)
Abstract (english): 
In this review, available experimental data on the drug confinement in porous matrices via adsorptive precipitation from supercritical fluid solutions with a special emphasis on the drug amorphization is provided. Practical aspects and opportunities for the process optimization are discussed in view of thermodynamic considerations. An attempt is made to elaborate a simplified model that takes into account drug–drug and drug-matrix interactions with the aim of rationalizing the experimental outcomes with respect to the physical state of the confined drug. Potential points of growth and some bottlenecks of the adsorptive precipitation from supercritical solutions are outlined.
URI: http://hdl.handle.net/11420/2417
ISSN: 0896-8446
Journal: The journal of supercritical fluids 
Institute: Thermische Verfahrenstechnik V-8 
Document Type: Review (Article)
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