Publisher DOI: | 10.1016/j.supflu.2017.03.005 | Title: | Amorphization of drugs by adsorptive precipitation from supercritical solutions: A review | Authors: | Gurikov, Pavel Smirnova, Irina ![]() |
Issue Date: | Feb-2018 | Source: | Journal of Supercritical Fluids (132): 105-125 (2018-02) | Abstract (english): | In this review, available experimental data on the drug confinement in porous matrices via adsorptive precipitation from supercritical fluid solutions with a special emphasis on the drug amorphization is provided. Practical aspects and opportunities for the process optimization are discussed in view of thermodynamic considerations. An attempt is made to elaborate a simplified model that takes into account drug–drug and drug-matrix interactions with the aim of rationalizing the experimental outcomes with respect to the physical state of the confined drug. Potential points of growth and some bottlenecks of the adsorptive precipitation from supercritical solutions are outlined. |
URI: | http://hdl.handle.net/11420/2417 | ISSN: | 0896-8446 | Journal: | The journal of supercritical fluids | Institute: | Thermische Verfahrenstechnik V-8 | Document Type: | Review (Article) |
Appears in Collections: | Publications without fulltext |
Show full item record
Page view(s)
134
Last Week
1
1
Last month
2
2
checked on Feb 5, 2023
SCOPUSTM
Citations
52
Last Week
1
1
Last month
0
0
checked on Jun 30, 2022
Google ScholarTM
Check
Add Files to Item
Note about this record
Cite this record
Export
Items in TORE are protected by copyright, with all rights reserved, unless otherwise indicated.