Amorphization of drugs by adsorptive precipitation from supercritical solutions: A review

Publikationstyp
Review Article
Date Issued
2018-02
Author(s)
Gurikov, Pavel  
Smirnova, Irina  orcid-logo
Institut
Thermische Verfahrenstechnik V-8  
TORE-URI
http://hdl.handle.net/11420/2417
Journal
The journal of supercritical fluids  
Start Page
105
End Page
125
Citation
Journal of Supercritical Fluids (132): 105-125 (2018-02)
Publisher DOI
10.1016/j.supflu.2017.03.005
Scopus ID
2-s2.0-85015330091
In this review, available experimental data on the drug confinement in porous matrices via adsorptive precipitation from supercritical fluid solutions with a special emphasis on the drug amorphization is provided. Practical aspects and opportunities for the process optimization are discussed in view of thermodynamic considerations. An attempt is made to elaborate a simplified model that takes into account drug–drug and drug-matrix interactions with the aim of rationalizing the experimental outcomes with respect to the physical state of the confined drug. Potential points of growth and some bottlenecks of the adsorptive precipitation from supercritical solutions are outlined.