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Publisher DOI: 10.1038/s41467-019-09704-x
Title: Human-sized magnetic particle imaging for brain applications
Language: English
Authors: Gräser, Matthias  
Thieben, Florian  
Szwargulski, Patryk 
Werner, Franziska 
Gdaniec, Nadine 
Boberg, Marija  
Griese, Florian  
Möddel, Martin 
Ludewig, Peter 
Ven, Dionys van de 
Weber, Oliver M. 
Woywode, Oliver 
Gleich, Bernhard 
Knopp, Tobias 
Issue Date: 26-Apr-2019
Publisher: Nature Publishing Group
Source: Nature communications (10): 1-9, art. no. 1936 (2019)
Journal or Series Name: Nature Communications 
Abstract (english): Determining the brain perfusion is an important task for diagnosis of vascular diseases such as occlusions and intracerebral haemorrhage. Even after successful diagnosis, there is a high risk of restenosis or rebleeding such that patients need intense attention in the days after treatment. Within this work, we present a diagnostic tomographic imager that allows access to brain perfusion quantitatively in short intervals. The device is based on the magnetic particle imaging technology and is designed for human scale. It is highly sensitive and allows the detection of an iron concentration of 263 pmolFe ml-1, which is one of the lowest iron concentrations imaged by MPI so far. The imager is self-shielded and can be used in unshielded environments such as intensive care units. In combination with the low technical requirements this opens up a variety of medical applications and would allow monitoring of stroke on intensive care units.
DOI: 10.15480/882.2233
ISSN: 2041-1723
Institute: Biomedizinische Bildgebung E-5 
Type: (wissenschaftlicher) Artikel
Funded by: German Research Foundation (DFG) grant number KN 1108/2-1
Project: Ganzkörper Magnetic-Particle-Imaging Messsequenzen 
License: CC BY 4.0 (Attribution) CC BY 4.0 (Attribution)
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