Publisher DOI: 10.1007/10_2016_9
Title: Engineering Biomolecular Switches for Dynamic Metabolic Control
Language: English
Authors: Ma, Cheng-Wei 
Zhou, Li-Bang 
Zeng, An-Ping 
Keywords: Biomolecular engineering;Bioswitches;Cellular regulation;Dynamic metabolic control;Strain development;Metabolic Engineering;Metabolism
Issue Date: 2018
Source: Advances in biochemical engineering/biotechnology (162): 45-76 (2018)
Journal or Series Name: Advances in biochemical engineering/biotechnology 
Abstract (english): Living organisms have been exploited as production hosts for a large variety of compounds. To improve the efficiency of bioproduction, metabolic pathways in an organism are usually manipulated by various genetic modifications. However, bottlenecks during the conversion of substrate to a desired product may result from cellular regulations at different levels. Dynamic regulation of metabolic pathways according to the need of cultivation process is therefore essential for developing effective bioprocesses, but represents a major challenge in metabolic engineering and synthetic biology. To this end, switchable biomolecules which can sense the intracellular concentrations of metabolites with different response types and dynamic ranges are of great interest. This chapter summarizes recent progress in the development of biomolecular switches and their applications for improvement of bioproduction via dynamic control of metabolic fluxes. Further studies of bioswitches and their applications in industrial strain development are also discussed.
URI: http://hdl.handle.net/11420/2592
ISBN: 978-3-319-55317-7
978-3-319-55318-4
ISSN: 0724-6145
Institute: Bioprozess- und Biosystemtechnik V-1 
Type: (wissenschaftlicher) Artikel
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