Engineering Biomolecular Switches for Dynamic Metabolic Control

Publikationstyp
Book Part
Date Issued
2018
Sprache
English
Author(s)
Ma, Cheng-Wei  
Zhou, Li-Bang  
Zeng, An-Ping  orcid-logo
Institut
Bioprozess- und Biosystemtechnik V-1  
TORE-URI
http://hdl.handle.net/11420/2592
First published in
Advances in biochemical engineering, biotechnology  
Number in series
162
Start Page
45
End Page
76
Citation
Synthetic Biology – Metabolic Engineering, Advances in biochemical engineering/biotechnology (162): 45-76 (2018)
Publisher DOI
10.1007/10_2016_9
Scopus ID
2-s2.0-85032588549
Living organisms have been exploited as production hosts for a large variety of compounds. To improve the efficiency of bioproduction, metabolic pathways in an organism are usually manipulated by various genetic modifications. However, bottlenecks during the conversion of substrate to a desired product may result from cellular regulations at different levels. Dynamic regulation of metabolic pathways according to the need of cultivation process is therefore essential for developing effective bioprocesses, but represents a major challenge in metabolic engineering and synthetic biology. To this end, switchable biomolecules which can sense the intracellular concentrations of metabolites with different response types and dynamic ranges are of great interest. This chapter summarizes recent progress in the development of biomolecular switches and their applications for improvement of bioproduction via dynamic control of metabolic fluxes. Further studies of bioswitches and their applications in industrial strain development are also discussed.
Subjects
Biomolecular engineering
Bioswitches
Cellular regulation
Dynamic metabolic control
Strain development
Metabolic Engineering
Metabolism