Publisher DOI: 10.1016/j.supflu.2019.04.013
Title: Alginate and hybrid alginate-hyaluronic acid aerogel microspheres as potential carrier for pulmonary drug delivery
Language: English
Authors: Athamneh, Tamara 
Amin, Adil 
Benke, Edit 
Ambrus, Rita 
Leopold, Claudia S. 
Gurikov, Pavel 
Smirnova, Irina  
Issue Date: Aug-2019
Source: Journal of Supercritical Fluids (150): 49-55 (2019-08)
Abstract (english): 
The aim of the present study was the preparation of aerogel microspheres based on alginate and hyaluronic acid for the potential application in pulmonary drug delivery. Both polymers are commonly used in the pharmaceutical and medical fields because of their nontoxicity, biodegradability and biocompatibility characteristics. The bio-based microspheres were produced using an emulsion gelation process with a subsequent drying step by supercritical CO 2 . The microspheres were characterized by FTIR and SEM. Furthermore, their BET surface area, particle size distribution, and their aerodynamic properties were determined. The microspheres showed a low density in the range of 0.035 – 0.063 g/cm 3 and a high porosity of 97.6–98.7 %, as well as good in vitro aerodynamic properties with d A values of about 5 μm. The obtained properties of the alginate- hyaluronic acid microspheres suggest that they are potentially suitable as drug carrier for pulmonary delivery.
ISSN: 0896-8446
Journal: The journal of supercritical fluids 
Institute: Thermische Verfahrenstechnik V-8 
Entwicklung und Modellierung neuartiger nanoporöser Materialien V-EXK2 
Document Type: Article
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