Publisher DOI: 10.1080/10837450.2017.1315135
Title: Significant solubility of carbon dioxide in Soluplus® facilitates impregnation of ibuprofen using supercritical fluid technology
Language: English
Authors: Obaidat, Rana 
Alnaief, Mohammad 
Jaeger, Philip 
Issue Date: 9-Aug-2018
Source: Pharmaceutical Development and Technology 7 (23): 697-705 (2018-08-09)
Journal or Series Name: Pharmaceutical development and technology 
Abstract (english): Treatment of Soluplus® with supercritical carbon dioxide allows promising applications in preparing dispersions of amorphous solids. Several characterization techniques were employed to reveal this effect, including CO2 gas sorption under high pressure and physicochemical characterizations techniques. A gravimetric method was used to determine the solubility of carbon dioxide in the polymer at elevated pressure. The following physicochemical characterizations were used: thermal analysis, X-ray diffraction, Fourier transform, infrared spectroscopy and scanning electron microscopy. Drug loading of the polymer with ibuprofen as a model drug was also investigated. The proposed treatment with supercritical carbon dioxide allows to prepare solid solutions of Soluplus® in less than two hours at temperatures that do not exceed 45 °C, which is a great advantage to be used for thermolabile drugs. The advantages of using this technology for Soluplus® formulations lies behind the high sorption capability of carbon dioxide inside the polymer. This will ensure rapid diffusion of the dissolved/dispersed drug inside the polymer under process conditions and rapid precipitation of the drug in the amorphous form during depressurization accompanied by foaming of the polymer.
ISSN: 1083-7450
Institute: Thermische Verfahrenstechnik V-8 
Type: (wissenschaftlicher) Artikel
Appears in Collections:Publications without fulltext

Show full item record

Page view(s)

Last Week
Last month
checked on Sep 22, 2020

Google ScholarTM


Add Files to Item

Note about this record


Items in TORE are protected by copyright, with all rights reserved, unless otherwise indicated.