DC FieldValueLanguage
dc.contributor.authorObaidat, Rana-
dc.contributor.authorAlnaief, Mohammad-
dc.contributor.authorJaeger, Philip-
dc.date.accessioned2019-07-02T12:29:02Z-
dc.date.available2019-07-02T12:29:02Z-
dc.date.issued2018-08-09-
dc.identifier.citationPharmaceutical Development and Technology 7 (23): 697-705 (2018-08-09)de_DE
dc.identifier.issn1083-7450de_DE
dc.identifier.urihttp://hdl.handle.net/11420/2866-
dc.description.abstractTreatment of Soluplus® with supercritical carbon dioxide allows promising applications in preparing dispersions of amorphous solids. Several characterization techniques were employed to reveal this effect, including CO2 gas sorption under high pressure and physicochemical characterizations techniques. A gravimetric method was used to determine the solubility of carbon dioxide in the polymer at elevated pressure. The following physicochemical characterizations were used: thermal analysis, X-ray diffraction, Fourier transform, infrared spectroscopy and scanning electron microscopy. Drug loading of the polymer with ibuprofen as a model drug was also investigated. The proposed treatment with supercritical carbon dioxide allows to prepare solid solutions of Soluplus® in less than two hours at temperatures that do not exceed 45 °C, which is a great advantage to be used for thermolabile drugs. The advantages of using this technology for Soluplus® formulations lies behind the high sorption capability of carbon dioxide inside the polymer. This will ensure rapid diffusion of the dissolved/dispersed drug inside the polymer under process conditions and rapid precipitation of the drug in the amorphous form during depressurization accompanied by foaming of the polymer.en
dc.language.isoende_DE
dc.relation.ispartofPharmaceutical development and technologyde_DE
dc.titleSignificant solubility of carbon dioxide in Soluplus® facilitates impregnation of ibuprofen using supercritical fluid technologyde_DE
dc.typeArticlede_DE
dc.type.diniarticle-
dcterms.DCMITypeText-
tuhh.abstract.englishTreatment of Soluplus® with supercritical carbon dioxide allows promising applications in preparing dispersions of amorphous solids. Several characterization techniques were employed to reveal this effect, including CO2 gas sorption under high pressure and physicochemical characterizations techniques. A gravimetric method was used to determine the solubility of carbon dioxide in the polymer at elevated pressure. The following physicochemical characterizations were used: thermal analysis, X-ray diffraction, Fourier transform, infrared spectroscopy and scanning electron microscopy. Drug loading of the polymer with ibuprofen as a model drug was also investigated. The proposed treatment with supercritical carbon dioxide allows to prepare solid solutions of Soluplus® in less than two hours at temperatures that do not exceed 45 °C, which is a great advantage to be used for thermolabile drugs. The advantages of using this technology for Soluplus® formulations lies behind the high sorption capability of carbon dioxide inside the polymer. This will ensure rapid diffusion of the dissolved/dispersed drug inside the polymer under process conditions and rapid precipitation of the drug in the amorphous form during depressurization accompanied by foaming of the polymer.de_DE
tuhh.publisher.doi10.1080/10837450.2017.1315135-
tuhh.publication.instituteThermische Verfahrenstechnik V-8de_DE
tuhh.type.opus(wissenschaftlicher) Artikel-
tuhh.institute.germanThermische Verfahrenstechnik V-8de
tuhh.institute.englishThermische Verfahrenstechnik V-8de_DE
tuhh.gvk.hasppnfalse-
dc.type.driverarticle-
dc.type.casraiJournal Article-
tuhh.container.issue7de_DE
tuhh.container.volume23de_DE
tuhh.container.startpage697de_DE
tuhh.container.endpage705de_DE
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.grantfulltextnone-
item.creatorOrcidObaidat, Rana-
item.creatorOrcidAlnaief, Mohammad-
item.creatorOrcidJaeger, Philip-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.creatorGNDObaidat, Rana-
item.creatorGNDAlnaief, Mohammad-
item.creatorGNDJaeger, Philip-
item.cerifentitytypePublications-
crisitem.author.deptThermische Verfahrenstechnik V-8-
crisitem.author.deptThermische Verfahrenstechnik V-8-
crisitem.author.orcid0000-0002-4714-9334-
crisitem.author.orcid0000-0002-6342-7314-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
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