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  4. Metronidazole within phosphatidylcholine lipid membranes: New insights to improve the design of imidazole derivatives
 
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Metronidazole within phosphatidylcholine lipid membranes: New insights to improve the design of imidazole derivatives

Publikationstyp
Journal Article
Date Issued
2018-08
Sprache
English
Author(s)
Lopes-de-Campos, Daniela  
Nunes, Cláudia  
Sarmento, Bruno  
Jakobtorweihen, Sven  
Reis, Salette  
Institut
Thermische Verfahrenstechnik V-8  
TORE-URI
http://hdl.handle.net/11420/2880
Journal
European journal of pharmaceutics and biopharmaceutics  
Volume
129
Start Page
204
End Page
214
Citation
European Journal of Pharmaceutics and Biopharmaceutics (129): 204-214 (2018-08)
Publisher DOI
10.1016/j.ejpb.2018.05.036
Scopus ID
2-s2.0-85048206435
Metronidazole is a imidazole derivative with antibacterial and antiprotozoal activity. Despite its therapeutic efficacy, several studies have been developing new imidazole derivatives with lower toxicity. Considering that drug-membrane interactions are key factors for drugs pharmacokinetic and pharmacodynamic properties, the aim of this work is to provide new insights into the structure–toxicity relationship of metronidazole within phosphatidylcholine membranes. For that purpose, lipid membrane models (liposomes and monolayers) composed of dipalmitoylphosphatidylcholine were used. Experimental techniques (determination of partition coefficients and Langmuir isotherm measurements) were combined with molecular dynamics simulations. Different pHs and lipid phases were evaluated to enable a better extrapolation for in vivo conditions. The partition of metronidazole depends on the pH and on the biphasic system (octanol/water or DPPC/water system). At pH 1.2, metronidazole is hydrophilic. At pH 7.4, metronidazole disturbs the order and the packing of phospholipids. For this toxic effect, the hydroxyl group of the side chain of metronidazole is crucial by interacting with the water embedded in the membrane and with the phosphate group and the apolar chains of phospholipids.
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