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Publisher DOI: 10.3390/lubricants3040664
Title: Development of a synthetic synovial fluid for tribological testing
Language: English
Authors: Bortel, Emely Lea 
Charbonnier, Baptiste 
Heuberger, Roman 
Keywords: Synthetic synovial fluid;viscosity;tribology;prosthesis testing;UHMWPE;polyethylene;CoCrMo
Issue Date: 1-Dec-2015
Publisher: MDPI
Source: Lubricants 4 (3): 664-686 (2015)
Journal or Series Name: Lubricants 
Abstract (english): Wear tests of joint prostheses are usually performed using bovine calf serum. The results from different laboratories are hardly ever comparable as, for example, the protein concentration and the protein composition of the serum-based test liquids vary. In addition, the viscosity of these test liquids is similar to that of water and does not match the more viscous synovial fluid. The present work was aimed at developing a synthetic synovial fluid as an alternative to the existing test liquids. Improved consistency and reproducibility of results at a similar price were required. Hyaluronic acid (HA), the lyophilized proteins bovine serum albumin (BSA) and immunoglobulin G (IgG), the phospholipid lecithin (PL) and salts were applied in a stepwise approach to replace the actually used test liquid based on newborn calf serum. The in vitro results obtained with ultra-high-molecular-weight polyethylene (UHMWPE) pins sliding against CoCrMo discs revealed that the developed synthetic synovial fluid fulfils the set requirements: increase of viscosity, reasonable cost, improved consistency and wear particles which resemble the ones found in vivo. The developed synthetic synovial fluid with 3 g/L HA, 19 g/L BSA, 11 g/L IgG, 0.1 g/L PL and Ringer solution is a more realistic alternative to the used serum-based test liquid.
DOI: 10.15480/882.2320
ISSN: 2075-4442
Institute: Keramische Hochleistungswerkstoffe M-9 
Type: (wissenschaftlicher) Artikel
License: CC BY 4.0 (Attribution) CC BY 4.0 (Attribution)
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