Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator

Chang Liao, Mei-Ling; Boer, Teun P. de; Mutoh, Hiroki; Raad, Nour; Richter, Claudia; Wagner, Eva; Downie, Bryan R.; Unsöld, Bernhard; Arooj, Iqra; Streckfuss-Bömeke, Katrin; Döker, Stephan; Luther, Stefan; Guan, Kaomei; Wagner, Stefan; Lehnart, Stephan E.; Maier, Lars S.; Stühmer, Walter; Wettwer, Erich; Veen, Toon van; Morlock, Michael

Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator

Publikationstyp

Journal Article

Date Issued

2015-08-14

Sprache

English

Institut

Biomechanik M-3

TORE-URI

http://hdl.handle.net/11420/2980

Journal

Circulation research

Volume

117

Issue

5

Start Page

401

End Page

412

Citation

Circulation research 5 (117): 401-412 (2015-08-14)

Publisher DOI

10.1161/CIRCRESAHA.117.306143

Scopus ID

2-s2.0-84939551716

Monitoring and controlling cardiac myocyte activity with optogenetic tools offer exciting possibilities for fundamental and translational cardiovascular research. Genetically encoded voltage indicators may be particularly attractive for minimal invasive and repeated assessments of cardiac excitation from the cellular to the whole heart level.

Subjects

arrhythmias, cardiac

electrophysiology

heart

myocytes, cardiac

optical imaging

optogenetics

stem cells

Options

Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator