|Publisher DOI:||10.1093/icvts/ivx289||Title:||Novel stent design for transcatheter mitral valve implantation||Language:||English||Authors:||Loger, Klaas
|Issue Date:||9-Oct-2017||Publisher:||Oxford Univ. Press||Source:||Interactive Cardiovascular and Thoracic Surgery 2 (26): 190-195 (2018-02-01)||Journal or Series Name:||Interactive cardiovascular and thoracic surgery||Abstract (english):||OBJECTIVES: In this study, results of a functional in vitro study of 2 newly developed valved stents for transcatheter mitral valve implantation are presented. METHODS: Two novel stent designs, an oval-shaped and a D-shaped stent with a strut fixation system were developed. The fixation force of the novel stents were tested in vitro in porcine hearts with a tensile test set-up. In further experiments, the stents were equipped with a circular valved stent, and the valve performances were investigated in a pulsatile heart valve tester. RESULTS: Sufficient mean stent fixation forces in the range of 24.2 ± 0.9N to 28.6 ± 1.9N were measured for the different stent models. The novel valved stents showed good performance in an in vitro pulsatile heart valve tester. A sufficient opening area and low opening pressures were measured for all tested mitral valved stents. Compared with an established reference valve, the D-shaped stent and the oval-shaped valved stent showed a lower systolic transvalvular pressure gradient, which indicates slightly greater extent of valvular leakage of the closed valved stents. However, the mitral nitinol valved stents demonstrated adequate durability. CONCLUSIONS: This study indicates a sufficient annular fixation force of the tested transcatheter mitral valve implantation valved stent prototypes. Therefore, these mitral valved stents demonstrate a new type of mitral valved stent design.||URI:||http://hdl.handle.net/11420/3024||ISSN:||1569-9285||Institute:||Biomechanik M-3||Type:||(wissenschaftlicher) Artikel|
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