Publisher DOI: 10.2298/JSC160422069M
Title: Original enzyme-catalyzed synthesis of chalcones: utilization of hydrolase promiscuity
Language: English
Authors: Mitrev, Yavor N. 
Mehandzhiyski, Aleksander Y. 
Batovska, Daniela I. 
Liese, Andreas  
Galunsky, Boris 
Issue Date: 2016
Publisher: Soc.
Source: Journal of the Serbian Chemical Society 11 (81): 1231-1237 (2016)
Journal or Series Name: Journal of the Serbian Chemical Society 
Abstract (english): An E-chalcone was obtained with very high stereoselectivity for the first time by an enzyme-catalyzed Claisen-Schmidt condensation between benzaldehyde and acetophenone. From a set of lipases, only that from hog pancreas demonstrated promiscuity, catalyzing the reaction in the presence of imidazole as a promoter. Another enzyme, acylase from Aspergillus melleus (EC 3.5.1.14) also proved to be active in the synthesis of E-chalcone under the same reaction conditions. This acylase along with the recombinant D-aminoacylase (EC 3.5.1.81) also catalyzed the reaction between acetophenone and p-nitrobenzaldehyde. Such a "green" approach to the synthesis of chalcones is of great interest because of the important applications of chalcones as formula ingredients in the pharmaceutical, food and cosmetic industries.
URI: http://hdl.handle.net/11420/3043
ISSN: 1820-7421
Institute: Technische Biokatalyse V-6 
Type: (wissenschaftlicher) Artikel
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