Publisher DOI: 10.3906/biy-1601-68
Title: Cytotoxicity and antibiofilm activity of SiO2/cellulose derivative hybrid materials containing silver nanoparticles
Language: English
Authors: Angelova, Tsvetelina 
Rangelova, Nadezhda 
Uzunova, Veselina 
Georgieva, Nelly 
Andreeva, Tonya 
Momchilova, Albena 
Tzoneva, Rumiana 
Müller, Rudolf 
Issue Date: 19-Apr-2016
Publisher: Tübitak
Source: Turkish Journal of Biology 6 (40): 1278-1288 (2016)
Journal or Series Name: Turkish journal of biology 
Abstract (english): Hybrid materials based on tetraethyl orthosilicate (TEOS), hydroxypropyl cellulose (HPC), or hydroxypropyl methyl cellulose (HPMC) with silver nanoparticles were synthesized. They were analyzed and characterized using differential thermal analysis and thermogravimetry, atomic force microscopy, and static contact angle measurements. It was experimentally demonstrated that the silverdoped hybrid materials have pronounced antibacterial behavior by studying the reduction of Pseudomonas aeruginosa PAO1 biofilm formation on the tested materials. The results revealed biofilm reduction of 35.7% and 30% by SiO 2 /HPC/2.5% Ag and SiO 2 /HPMC/2.5% Ag hybrid materials, respectively, compared to the control. Cytotoxicity of examined materials and actin cytoskeleton organization of fibroblasts seeded on the materials was studied as a function of material properties as the type of surface functional groups and silver content. The obtained hybrid materials with low silver content proved efficient in tissue engineering applications since they showed good antibacterial and noncytotoxic properties for eukaryotic cells.
URI: http://hdl.handle.net/11420/3044
ISSN: 1303-6092
Institute: Technische Biokatalyse V-6 
Type: (wissenschaftlicher) Artikel
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