DC FieldValueLanguage
dc.contributor.authorMaquer, Ghislain-
dc.contributor.authorLu, Yongtao-
dc.contributor.authorDall'Ara, Enrico-
dc.contributor.authorChevalier, Yan-
dc.contributor.authorKrause, Matthias-
dc.contributor.authorYang, Lang-
dc.contributor.authorEastell, Richard-
dc.contributor.authorLippuner, Kurt-
dc.contributor.authorZysset, Philippe K.-
dc.date.accessioned2019-08-02T06:48:56Z-
dc.date.available2019-08-02T06:48:56Z-
dc.date.issued2016-08-01-
dc.identifier.citationJournal of Bone and Mineral Research 2 (31): 341-346 (2016-02-01)de_DE
dc.identifier.issn1523-4681de_DE
dc.identifier.urihttp://hdl.handle.net/11420/3048-
dc.description.abstractTrabecular bone score (TBS) rests on the textural analysis of dual-energy X-ray absorptiometry (DXA) to reflect the decay in trabecular structure characterizing osteoporosis. Yet, its discriminative power in fracture studies remains incomprehensible because prior biomechanical tests found no correlation with vertebral strength. To verify this result possibly owing to an unrealistic setup and to cover a wide range of loading scenarios, the data from three previous biomechanical studies using different experimental settings were used. They involved the compressive failure of 62 human lumbar vertebrae loaded 1) via intervertebral discs to mimic the in vivo situation ("full vertebra"); 2) via the classical endplate embedding ("vertebral body"); or 3) via a ball joint to induce anterior wedge failure ("vertebral section"). High-resolution peripheral quantitative computed tomography (HR-pQCT) scans acquired from prior testing were used to simulate anterior-posterior DXA from which areal bone mineral density (aBMD) and the initial slope of the variogram (ISV), the early definition of TBS, were evaluated. Finally, the relation of aBMD and ISV with failure load (F exp ) and apparent failure stress (σ exp ) was assessed, and their relative contribution to a multilinear model was quantified via ANOVA. We found that, unlike aBMD, ISV did not significantly correlate with F exp and σ exp , except for the "vertebral body" case (r 2 = 0.396, p = 0.028). Aside from the "vertebra section" setup where it explained only 6.4% of σ exp (p = 0.037), it brought no significant improvement to aBMD. These results indicate that ISV, a replica of TBS, is a poor surrogate for vertebral strength no matter the testing setup, which supports the prior observations and raises a fortiori the question of the deterministic factors underlying the statistical relationship between TBS and vertebral fracture risk.en
dc.language.isoende_DE
dc.publisherWileyde_DE
dc.relation.ispartofJournal of bone and mineral researchde_DE
dc.subject.ddc570: Biowissenschaften, Biologiede_DE
dc.subject.ddc610: Medizinde_DE
dc.titleThe initial slope of the variogram, foundation of the trabecular bone score, is not or is poorly associated with vertebral strengthde_DE
dc.typeArticlede_DE
dc.type.diniarticle-
dc.subject.ddccode610-
dc.subject.ddccode570-
dcterms.DCMITypeText-
tuhh.abstract.englishTrabecular bone score (TBS) rests on the textural analysis of dual-energy X-ray absorptiometry (DXA) to reflect the decay in trabecular structure characterizing osteoporosis. Yet, its discriminative power in fracture studies remains incomprehensible because prior biomechanical tests found no correlation with vertebral strength. To verify this result possibly owing to an unrealistic setup and to cover a wide range of loading scenarios, the data from three previous biomechanical studies using different experimental settings were used. They involved the compressive failure of 62 human lumbar vertebrae loaded 1) via intervertebral discs to mimic the in vivo situation ("full vertebra"); 2) via the classical endplate embedding ("vertebral body"); or 3) via a ball joint to induce anterior wedge failure ("vertebral section"). High-resolution peripheral quantitative computed tomography (HR-pQCT) scans acquired from prior testing were used to simulate anterior-posterior DXA from which areal bone mineral density (aBMD) and the initial slope of the variogram (ISV), the early definition of TBS, were evaluated. Finally, the relation of aBMD and ISV with failure load (F exp ) and apparent failure stress (σ exp ) was assessed, and their relative contribution to a multilinear model was quantified via ANOVA. We found that, unlike aBMD, ISV did not significantly correlate with F exp and σ exp , except for the "vertebral body" case (r 2 = 0.396, p = 0.028). Aside from the "vertebra section" setup where it explained only 6.4% of σ exp (p = 0.037), it brought no significant improvement to aBMD. These results indicate that ISV, a replica of TBS, is a poor surrogate for vertebral strength no matter the testing setup, which supports the prior observations and raises a fortiori the question of the deterministic factors underlying the statistical relationship between TBS and vertebral fracture risk.de_DE
tuhh.publisher.doi10.1002/jbmr.2610-
tuhh.publication.instituteBiomechanik M-3de_DE
tuhh.type.opus(wissenschaftlicher) Artikel-
tuhh.institute.germanBiomechanik M-3de
tuhh.institute.englishBiomechanik M-3de_DE
tuhh.gvk.hasppnfalse-
dc.type.driverarticle-
dc.type.casraiJournal Article-
tuhh.container.issue2de_DE
tuhh.container.volume31de_DE
tuhh.container.startpage341de_DE
tuhh.container.endpage346de_DE
item.creatorGNDMaquer, Ghislain-
item.creatorGNDLu, Yongtao-
item.creatorGNDDall'Ara, Enrico-
item.creatorGNDChevalier, Yan-
item.creatorGNDKrause, Matthias-
item.creatorGNDYang, Lang-
item.creatorGNDEastell, Richard-
item.creatorGNDLippuner, Kurt-
item.creatorGNDZysset, Philippe K.-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.grantfulltextnone-
item.creatorOrcidMaquer, Ghislain-
item.creatorOrcidLu, Yongtao-
item.creatorOrcidDall'Ara, Enrico-
item.creatorOrcidChevalier, Yan-
item.creatorOrcidKrause, Matthias-
item.creatorOrcidYang, Lang-
item.creatorOrcidEastell, Richard-
item.creatorOrcidLippuner, Kurt-
item.creatorOrcidZysset, Philippe K.-
crisitem.author.deptBiomechanik M-3-
crisitem.author.orcid0000-0002-8511-6111-
crisitem.author.orcid0000-0003-1471-5077-
crisitem.author.orcid0000-0002-7345-6506-
crisitem.author.parentorgStudiendekanat Maschinenbau-
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