Publisher DOI: 10.1088/0031-9155/61/9/3279
Title: Increasing the sensitivity for stem cell monitoring in system-function based magnetic particle imaging
Authors: Them, Kolja 
Salamon, Johannes 
Szwargulski, Patryk 
Sequeira, S. 
Kaul, Michael 
Lange, Claudia 
Ittrich, Harald 
Knopp, Tobias 
Keywords: magnetic particle imaging;superparamagnetic iron oxide nanoparticles;stem cell monitoring;sensitivity
Issue Date: 1-Apr-2016
Publisher: IOP
Source: Physics in Medicine and Biology 9 (61): 3279-3290 (2016-04-01)
Journal or Series Name: Physics in medicine and biology 
Abstract (english): The use of superparamagnetic iron oxide nanoparticles (SPIONs) has provided new possibilities in biophysics and biomedical imaging technologies. The magnetization dynamics of SPIONs, which can be influenced by the environment, are of central interest. In this work, different biological SPION environments are used to investigate three different calibration methods for stem cell monitoring in magnetic particle imaging. It is shown that calibrating using SPIONs immobilized via agarose gel or intracellular uptake results in superior stem cell image quality compared to mobile SPIONs in saline. This superior image quality enables more sensitive localization and identification of a significantly smaller number of magnetically labeled stem cells. The results are important for cell tracking and monitoring of future SPION based therapies such as hyperthermia based cancer therapies, targeted drug delivery, or tissue regeneration approaches where it is crucial to image a sufficiently small number of SPIONs interacting with biological matter.
ISSN: 0031-9155
Institute: Biomedizinische Bildgebung E-5 
Type: (wissenschaftlicher) Artikel
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