Publisher DOI: | 10.1016/j.supflu.2019.104545 | Title: | Alginate aerogels carrying calcium, zinc and silver cations for wound care: Fabrication and metal detection | Language: | English | Authors: | Subrahmanyam, Raman Keil, Claudia Dieringer, Paul Hübner, Christopher Morales, Alberto Bueno Gurikov, Pavel Nissen, Jörg Holtkamp, Manuel Karst, Uwe Haase, Hajo Smirnova, Irina ![]() |
Issue Date: | Nov-2019 | Source: | Journal of Supercritical Fluids (153): 104545 (2019-11) | Abstract (english): | Calcium-alginate aerogels augmented with zinc and silver can provide the next generation superabsorbent medical devices for advanced wound care with high cell and tissue tolerability and controlled compound release rates during wound healing. In this study, we addressed the fabrication and metal detection of alginate-based aerogels with these immunoactive cations. All three cations were incorporated into the alginate aerogel, albeit in different quantities, due to different magnitudes of leaching during solvent exchange step; an effect not reported previously. Silver addition led to an increase in aerogel zinc content without influencing calcium incorporation. All three metal ions were released into supernatants upon swelling aerogels in aqueous solutions, comparable to those measured for common wound dressings in human and animal injury models. The in vitro bioactivity studies showed that Zn-enriched swelling supernatants were able to suppress NO production in stimulated RAW 264.7 macrophages, indicating an effective anti-inflammatory activity. |
URI: | http://hdl.handle.net/11420/3133 | ISSN: | 0896-8446 | Journal: | The journal of supercritical fluids | Institute: | Thermische Verfahrenstechnik V-8 Entwicklung und Modellierung neuartiger nanoporöser Materialien V-EXK2 |
Document Type: | Article | More Funding information: | Financial support from DFG (project SM 82/13-1) is gratefully acknowledged. |
Appears in Collections: | Publications without fulltext |
Show full item record
Page view(s)
316
Last Week
1
1
Last month
23
23
checked on Feb 6, 2023
SCOPUSTM
Citations
27
Last Week
0
0
Last month
0
0
checked on Jun 30, 2022
Google ScholarTM
Check
Add Files to Item
Note about this record
Cite this record
Export
Items in TORE are protected by copyright, with all rights reserved, unless otherwise indicated.