Publisher DOI: 10.1016/j.supflu.2019.104545
Title: Alginate aerogels carrying calcium, zinc and silver cations for wound care: Fabrication and metal detection
Language: English
Authors: Subrahmanyam, Raman 
Keil, Claudia 
Dieringer, Paul 
Hübner, Christopher 
Morales, Alberto Bueno 
Gurikov, Pavel 
Nissen, Jörg 
Holtkamp, Manuel 
Karst, Uwe 
Haase, Hajo 
Smirnova, Irina  
Issue Date: Nov-2019
Source: Journal of Supercritical Fluids (153): 104545 (2019-11)
Abstract (english): 
Calcium-alginate aerogels augmented with zinc and silver can provide the next generation superabsorbent medical devices for advanced wound care with high cell and tissue tolerability and controlled compound release rates during wound healing. In this study, we addressed the fabrication and metal detection of alginate-based aerogels with these immunoactive cations. All three cations were incorporated into the alginate aerogel, albeit in different quantities, due to different magnitudes of leaching during solvent exchange step; an effect not reported previously. Silver addition led to an increase in aerogel zinc content without influencing calcium incorporation. All three metal ions were released into supernatants upon swelling aerogels in aqueous solutions, comparable to those measured for common wound dressings in human and animal injury models. The in vitro bioactivity studies showed that Zn-enriched swelling supernatants were able to suppress NO production in stimulated RAW 264.7 macrophages, indicating an effective anti-inflammatory activity.
ISSN: 0896-8446
Journal: The journal of supercritical fluids 
Institute: Thermische Verfahrenstechnik V-8 
Entwicklung und Modellierung neuartiger nanoporöser Materialien V-EXK2 
Document Type: Article
More Funding information: Financial support from DFG (project SM 82/13-1) is gratefully acknowledged.
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