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  4. Preparation of macroporous alginate-based aerogels for biomedical applications
 
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Preparation of macroporous alginate-based aerogels for biomedical applications

Publikationstyp
Journal Article
Date Issued
2015-11
Sprache
English
Author(s)
Martins, Marta  
Barros, Alexandre A.  
Quraishi, Sakeena  
Gurikov, Pavel  
Subrahmanyam, Raman  
Smirnova, Irina  orcid-logo
Duarte, Ana Rita C.  
Reis, Rui L.  
Institut
Thermische Verfahrenstechnik V-8  
TORE-URI
http://hdl.handle.net/11420/3145
Journal
The journal of supercritical fluids  
Volume
106
Start Page
152
End Page
159
Citation
Journal of Supercritical Fluids (106): 152-159 (2015)
Publisher DOI
10.1016/j.supflu.2015.05.010
Scopus ID
2-s2.0-84930166827
Publisher
Elsevier Science
Aerogels are a special class of ultra-light porous materials with growing interest in biomedical applications due to their open pore structure and high surface area. However, they usually lack macroporosity, while mesoporosity is typically high. In this work, carbon dioxide induced gelation followed by expansion of the dissolved CO2 was performed to produce hybrid calcium-crosslinked alginate-starch hydrogels with dual meso- and macroporosity. The hydrogels were subjected to solvent exchange and supercritical drying to obtain aerogels. Significant increase in macroporosity from 2 to 25% was achieved by increasing expansion rate from 0.1 to 30 bar/min with retaining mesoporosity (BET surface and BJH pore volume in the range 183-544m2/g and 2.0-6.8cm3/g, respectively). In vitro bioactivity studies showed that the alginate-starch aerogels are bioactive, i.e. they form hydroxyapatite crystals when immersed in a simulated body fluid solution. Bioactivity is attributed to the presence of calcium in the matrix. The assessment of the biological performance showed that the aerogels do not present a cytotoxic effect and the cells are able to colonize and grow on their surface. Results presented in this work provide a good indication of the potential of the alginate-starch aerogels in biomedical applications, particularly for bone regeneration.
Subjects
Aerogels
Alginate
Starch
Tissue engineering
Supercritical fluids
CO2 induced gelation
DDC Class
600: Technik
620: Ingenieurwissenschaften
More Funding Information
Support from Fundação da Ciência e Tecnologia (FCT) through the grant BIM/PTDC/EQU-EPR/121491/2010/ENIGMA. B ilateral 3B’s Research Group and TUHH cooperation project FCT-DAAD 57,036,335 and DFG project SM82/8-2 are gratefully acknowledged
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