DC FieldValueLanguage
dc.contributor.authorKühn, Steffen-
dc.contributor.authorSluyter, Gerrit-
dc.contributor.authorChristlieb, Marc-Andreas-
dc.contributor.authorHeils, Rene-
dc.contributor.authorStöbener, Anne-Kathrin Christine-
dc.contributor.authorKleber, Joscha-
dc.contributor.authorSmirnova, Irina-
dc.contributor.authorLiese, Andreas-
dc.date.accessioned2019-08-21T11:21:01Z-
dc.date.available2019-08-21T11:21:01Z-
dc.date.issued2017-06-07-
dc.identifier.citationIndustrial and Engineering Chemistry Research 22 (56): 6451-6461 (2017-06-07)de_DE
dc.identifier.issn1520-5045de_DE
dc.identifier.urihttp://hdl.handle.net/11420/3154-
dc.description.abstractIn situ separation of a chiral target compound is realized for the first time as distillate on top of an integrated biocatalytic batch reactive distillation column. The applied reaction system is the racemic resolution of (R/S)-2-pentanol in a transesterification with propyl butyrate, which is catalyzed by immobilized Candida antarctica lipase B (Novozym435). Biocatalyst integration is realized in baskets of wire gauze catalytic packings as column internals. The equilibrium limited reaction is shifted to the product side by fractional distillation of low boiling propanol and the target compound (S)-2-pentanol. Increased molar fractions up to x(S)-2-PeOH = 65 ± 4% with an enantiomeric excess of 90 ± 4% and 51 ± 3% overall conversion are reached for (S)-2-pentanol. Feasibility of the reaction system is investigated in our preselection tool. This tool is developed to evaluate predefined operation conditions in the column setup for transesterification reactions based on criteria regarding biocatalyst stability and boiling point differences between the reactants. The subsequently selected reaction of (R/S)-2-pentanol with propyl butyrate is successfully carried out in a batch reactive distillation column with in situ separation of our target compound (S)-2-pentanol. In contrast to current examples in the literature, this clearly demonstrates the possibility of one-pot target compound isolation within chiral synthesis applying biocatalytic reactive distillation.en
dc.description.sponsorshipFunding by the German Research Association (DFG LI 899/8-3 and SM 82/9-3) to reach the presented results.de_DE
dc.language.isoende_DE
dc.publisherAmerican Chemical Societyde_DE
dc.relation.ispartofIndustrial & engineering chemistry researchde_DE
dc.subject.ddc570: Biowissenschaften, Biologiede_DE
dc.subject.ddc620: Ingenieurwissenschaftende_DE
dc.titleIn situ separation of the chiral target compound (S)-2-pentanol in biocatalytic reactive distillationde_DE
dc.typeArticlede_DE
dc.type.diniarticle-
dc.subject.ddccode620-
dc.subject.ddccode570-
dcterms.DCMITypeText-
tuhh.abstract.englishIn situ separation of a chiral target compound is realized for the first time as distillate on top of an integrated biocatalytic batch reactive distillation column. The applied reaction system is the racemic resolution of (R/S)-2-pentanol in a transesterification with propyl butyrate, which is catalyzed by immobilized Candida antarctica lipase B (Novozym435). Biocatalyst integration is realized in baskets of wire gauze catalytic packings as column internals. The equilibrium limited reaction is shifted to the product side by fractional distillation of low boiling propanol and the target compound (S)-2-pentanol. Increased molar fractions up to x(S)-2-PeOH = 65 ± 4% with an enantiomeric excess of 90 ± 4% and 51 ± 3% overall conversion are reached for (S)-2-pentanol. Feasibility of the reaction system is investigated in our preselection tool. This tool is developed to evaluate predefined operation conditions in the column setup for transesterification reactions based on criteria regarding biocatalyst stability and boiling point differences between the reactants. The subsequently selected reaction of (R/S)-2-pentanol with propyl butyrate is successfully carried out in a batch reactive distillation column with in situ separation of our target compound (S)-2-pentanol. In contrast to current examples in the literature, this clearly demonstrates the possibility of one-pot target compound isolation within chiral synthesis applying biocatalytic reactive distillation.de_DE
tuhh.publisher.doi10.1021/acs.iecr.7b01163-
tuhh.publication.instituteTechnische Biokatalyse V-6de_DE
tuhh.publication.instituteThermische Verfahrenstechnik V-8de_DE
tuhh.type.opus(wissenschaftlicher) Artikel-
tuhh.institute.germanThermische Verfahrenstechnik V-8de
tuhh.institute.englishThermische Verfahrenstechnik V-8de_DE
tuhh.gvk.hasppnfalse-
dc.type.driverarticle-
dc.type.casraiJournal Article-
tuhh.container.issue22de_DE
tuhh.container.volume56de_DE
tuhh.container.startpage6451de_DE
tuhh.container.endpage6461de_DE
item.creatorGNDKühn, Steffen-
item.creatorGNDSluyter, Gerrit-
item.creatorGNDChristlieb, Marc-Andreas-
item.creatorGNDHeils, Rene-
item.creatorGNDStöbener, Anne-Kathrin Christine-
item.creatorGNDKleber, Joscha-
item.creatorGNDSmirnova, Irina-
item.creatorGNDLiese, Andreas-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.grantfulltextnone-
item.creatorOrcidKühn, Steffen-
item.creatorOrcidSluyter, Gerrit-
item.creatorOrcidChristlieb, Marc-Andreas-
item.creatorOrcidHeils, Rene-
item.creatorOrcidStöbener, Anne-Kathrin Christine-
item.creatorOrcidKleber, Joscha-
item.creatorOrcidSmirnova, Irina-
item.creatorOrcidLiese, Andreas-
crisitem.author.deptTechnische Biokatalyse V-6-
crisitem.author.deptTechnische Biokatalyse V-6-
crisitem.author.deptTechnische Biokatalyse V-6-
crisitem.author.deptThermische Verfahrenstechnik V-8-
crisitem.author.deptTechnische Biokatalyse V-6-
crisitem.author.deptTechnische Biokatalyse V-6-
crisitem.author.deptThermische Verfahrenstechnik V-8-
crisitem.author.deptTechnische Biokatalyse V-6-
crisitem.author.orcid0000-0003-4503-4039-
crisitem.author.orcid0000-0002-4867-9935-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
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