Publisher DOI: 10.1039/c6gc02529c
Title: An alternative approach towards poly-ε-caprolactone through a chemoenzymatic synthesis: combined hydrogenation, bio-oxidations and polymerization without the isolation of intermediates
Language: English
Authors: Wedde, Severin 
Rommelmann, Philipp 
Scherkus, Christian 
Schmidt, Sandy 
Bornscheuer, Uwe Theo 
Liese, Andreas  
Gröger, Harald 
Issue Date: 6-Jan-2017
Publisher: RSC
Source: Green Chemistry 5 (19): 1286-1290 (2017-06-01)
Journal or Series Name: Green chemistry 
Abstract (english): A novel synthetic route towards the polymer poly-ε-caprolactone based on a chemoenzymatic reaction sequence was developed. Initial hydrogenation of phenol to cyclohexanol gave a crude product, which was directly used without work-up for a subsequent biocatalytic double oxidation towards ε-caprolactone by means of an alcohol dehydrogenase and a monooxygenase. In order to overcome product inhibition effects, an in situ-product removal strategy via extraction of ε-caprolactone from an aqueous reaction medium with an organic solvent in the presence of a permeable polydimethylsiloxane membrane was applied. Furthermore, this in situ-product removal was combined with lipase-catalyzed polymerization in the organic phase at 25 °C. The obtained crude product contained a polymer fraction with a degree of polymerization comparable to commercial poly-ε-caprolactone.
URI: http://hdl.handle.net/11420/3158
ISSN: 1463-9270
Institute: Technische Biokatalyse V-6 
Type: (wissenschaftlicher) Artikel
Appears in Collections:Publications without fulltext

Show full item record

Page view(s)

38
Last Week
0
Last month
2
checked on Sep 28, 2020

Google ScholarTM

Check

Add Files to Item

Note about this record

Export

Items in TORE are protected by copyright, with all rights reserved, unless otherwise indicated.