Publisher DOI: 10.1039/c6gc02529c
Title: An alternative approach towards poly-ε-caprolactone through a chemoenzymatic synthesis: combined hydrogenation, bio-oxidations and polymerization without the isolation of intermediates
Language: English
Authors: Wedde, Severin 
Rommelmann, Philipp 
Scherkus, Christian 
Schmidt, Sandy 
Bornscheuer, Uwe Theo 
Liese, Andreas  
Gröger, Harald 
Issue Date: 6-Jan-2017
Publisher: RSC
Source: Green Chemistry 5 (19): 1286-1290 (2017-06-01)
Journal or Series Name: Green chemistry 
Abstract (english): A novel synthetic route towards the polymer poly-ε-caprolactone based on a chemoenzymatic reaction sequence was developed. Initial hydrogenation of phenol to cyclohexanol gave a crude product, which was directly used without work-up for a subsequent biocatalytic double oxidation towards ε-caprolactone by means of an alcohol dehydrogenase and a monooxygenase. In order to overcome product inhibition effects, an in situ-product removal strategy via extraction of ε-caprolactone from an aqueous reaction medium with an organic solvent in the presence of a permeable polydimethylsiloxane membrane was applied. Furthermore, this in situ-product removal was combined with lipase-catalyzed polymerization in the organic phase at 25 °C. The obtained crude product contained a polymer fraction with a degree of polymerization comparable to commercial poly-ε-caprolactone.
ISSN: 1463-9270
Institute: Technische Biokatalyse V-6 
Type: (wissenschaftlicher) Artikel
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