Publisher DOI: 10.1016/j.supflu.2017.02.015
Title: Influence of chemical nature of carrier materials on the dissolution behavior of racemic ibuprofen
Language: English
Authors: Reiser, Sarah 
Sun, Miaotian 
Johannsen, Monika  
Türk, Michael 
Issue Date: Feb-2018
Source: Journal of Supercritical Fluids (132): 91-98 (2018-02)
Abstract (english): 
The poor aqueous solubility of ibuprofen due to its hydrophobicity limits the bioavailability of the drug in the aqueous environment of the human body. Therefore particle deposition experiments were performed with ibuprofen and different carrier materials. Furthermore, the dissolution behavior of the untreated ibuprofen and the ibuprofen loaded carriers has been investigated at 310 K and pH = 2.0 and pH = 5.5. The results of this investigation demonstrate that drug loadings up to 50 wt% drug onto silica materials could be achieved and that the drug loading increases nearly linear with increasing surface area of the silica materials. Furthermore, the study reveals that the highest dissolution rate was obtained with β-cyclodextrin and that the dissolution rate of all materials investigated increases with increasing pHvalue.
ISSN: 0896-8446
Journal: The journal of supercritical fluids 
Institute: Thermische Verfahrenstechnik V-8 
Document Type: Article
More Funding information: This work was supported by the grants TU 93/18-1 and JO 339/8-1 of the DFG (Deutsche Forschungsgesellschaft).
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