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  4. Robotic ultrasound-guided SBRT of the prostate: feasibility with respect to plan quality
 
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Robotic ultrasound-guided SBRT of the prostate: feasibility with respect to plan quality

Publikationstyp
Journal Article
Date Issued
2016-07-12
Sprache
English
Author(s)
Gerlach, Stefan  orcid-logo
Kuhlemann, Ivo  
Jauer, Philipp  
Bruder, Ralf  
Ernst, Floris  
Fürweger, Christoph  
Schlaefer, Alexander  
Institut
Medizintechnische Systeme E-1  
TORE-URI
http://hdl.handle.net/11420/3406
Journal
International journal of computer assisted radiology and surgery  
Volume
12
Issue
1
Start Page
149
End Page
159
Citation
International Journal of Computer Assisted Radiology and Surgery 1 (12): 149-159 (2017)
Publisher DOI
10.1007/s11548-016-1455-7
Scopus ID
2-s2.0-84978038900
Publisher
Springer
Advances in radiation therapy delivery systems have enabled motion compensated SBRT of the prostate. A remaining challenge is the integration of fast, non-ionizing volumetric imaging. Recently, robotic ultrasound has been proposed as an intra-fraction image modality. We study the impact of integrating a light-weight robotic arm carrying an ultrasound probe with the CyberKnife system. Particularly, we analyze the effect of different robot poses on the plan quality. Methods: A method to detect the collision of beams with the robot or the transducer was developed and integrated into our treatment planning system. A safety margin accounts for beam motion and uncertainties. Using strict dose bounds and the objective to maximize target coverage, we generated a total of 7650 treatment plans for five different prostate cases. For each case, ten different poses of the ultrasound robot and transducer were considered. The effect of different sets of beam source positions and different motion margins ranging from 5 to 50 mm was analyzed. Results: Compared to reference plans without the ultrasound robot, the coverage typically drops for all poses. Depending on the patient, the robot pose, and the motion margin, the reduction in coverage may be up to 50 % points. However, for all patient cases, there exist poses for which the loss in coverage was below 1 % point for motion margins of up to 20 mm. In general, there is a positive correlation between the number of treatment beams and the coverage. Conclusion: While the blocking of beam directions has a negative effect on the plan quality, the results indicate that a careful choice of the ultrasound robot’s pose and a large solid angle covered by beam starting positions can offset this effect. Identifying robot poses that yield acceptable plan quality and allow for intra-fraction ultrasound image guidance, therefore, appears feasible.
Subjects
CyberKnife
Image-guided radiation therapy
Robotics
SBRT
Treatment planning
Ultrasound
DDC Class
600: Technik
610: Medizin
More Funding Information
Funded by Deutsche Forschungsgemeinschaft (Grants ER 817/1-1 and SCHL 1844/3-1).
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