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Publisher DOI: 10.1515/cdbme-2019-0048
Title: 3D printed anatomical model of a rat for medical imaging
Language: English
Authors: Exner, Miriam 
Szwargulski, Patryk 
Knopp, Tobias 
Gräser, Matthias  
Ludewig, Peter 
Keywords: 3D Printing;Magnetic Particle Imaging;Rat Model
Issue Date: 18-Sep-2019
Publisher: De Gruyter
Source: Current Directions in Biomedical Engineering 1 (5): 187-190 (2019)
Journal or Series Name: Current directions in biomedical engineering 
Is supplemented by: 10.5281/zenodo.3598649
Abstract (english): For medical research, approximately 115 million animals are needed every year. Rodents are used to test possible applications and procedures for the diagnosis of anatomical and physiological diseases. However, working with living animals increases the complexity of an experiment. Accurate experimental planning is essential in order to fulfill the 3R rules (replace, reduce and refine). Especially in tracer-based imaging modalities, such as magnetic particle imaging (MPI), where only nanoparticles give a positive contrast, the anatomical structure of the rodent is not visible without co-registration with another imaging modality. This leads to problems in the experimental planning, as parameters, such as field of view, rodent position and tracer concentration, have to be determined without visual feedback. In this work, a 3D CAD rat model is presented, which can be used to improve the experiment planning and thus reduce the number of animals required. It was determined using an anatomy atlas and 3D printed with stereolithography. The resulting model contains the most important organs and vessels as hollow cavities. By filling these with appropriate tracer materials, the phantom can be used in different imaging modalities such as MPI, magnetic resonance imaging (MRI) or computed tomography (CT). In a first MPI measurement, the phantom was filled with superparamagnetic nanoparticles. Finally, a successful visualization of all organs and vessels of the phantom was possible. This enables the planning of the experiment and the optimization of experimental parameters for a region of interest, where certain organs in a living animal are localized.
DOI: 10.15480/882.2419
ISSN: 2364-5504
Institute: Biomedizinische Bildgebung E-5 
Type: (wissenschaftlicher) Artikel
Funded by: Research funding: The authors thankfully acknowledge the financial support by the DFG (grant number KN 1108/2-1) and the BMBF (grant number 05M16GKA).
Project: Ganzkörper Magnetic-Particle-Imaging Messsequenzen 
License: CC BY 4.0 (Attribution) CC BY 4.0 (Attribution)
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