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Standardized qualification of stirred bioreactors for microbial biopharmaceutical production processes
Publikationstyp
Journal Article
Date Issued
2017-10-20
Sprache
English
Institut
TORE-URI
Journal
Volume
89
Issue
12
Start Page
1766
End Page
1772
Citation
Chemie-Ingenieur-Technik 12 (89): 1766-1772 (2017-12-01)
Publisher DOI
Scopus ID
Publisher
Wiley-VCH Verl.
An in 2016 published DECHEMA guideline concerning process engineering characterization and a new Escherichia coli model process were utilized for the qualification of two geometrically similar stirred stainless steel bioreactors (30 L and 100 L working volume). The achieved results demonstrate that performing an additional biological model process is a valuable complement to the process engineering characterization. Optical densities of 27 (100 L) and 39 (30 L) were reached in the batch cultivation process.
Subjects
Escherichia coli
Mixing time
Process engineering characterization
Specific power input
Stirred bioreactor
Volumetric mass transfer coefficient
DDC Class
600: Technik
620: Ingenieurwissenschaften