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  4. Articulation of an alumina-zirconia composite ceramic against living cartilage – An in vitro wear test
 
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Articulation of an alumina-zirconia composite ceramic against living cartilage – An in vitro wear test

Publikationstyp
Journal Article
Date Issued
2020-03
Sprache
English
Author(s)
Wimmer, Markus A.  
Pacione, Carol  
Yuh, Catherine  
Chan, Yuet Ming  
Kunze, Joachim  
Laurent, Michel P.  
Chubinskaya, Susan  
Institut
Zentrallabor Chemische Analytik L  
TORE-URI
http://hdl.handle.net/11420/3865
Journal
Journal of the mechanical behavior of biomedical materials  
Volume
103
Article Number
103531
Citation
Journal of the Mechanical Behavior of Biomedical Materials (103): 103531 (2020-03)
Publisher DOI
10.1016/j.jmbbm.2019.103531
Scopus ID
2-s2.0-85075085439
Background: There is interest in minimally invasive solutions that reduce osteoarthritic symptoms and restore joint mobility in the early stages of cartilage degeneration. The aim of the present study was to evaluate an alumina-zirconia composite (AZC) as a counterface for articulation against live cartilage explants in comparison to the clinically relevant cobalt-chromium (CoCrMo) alloy. Methods: A four-station bioreactor designed to articulate against living tissue in an incubator was used for testing. Twelve 32 mm AZC and twelve 32 mm CoCrMo femoral heads with equal surface roughness made up both test groups. Each head articulated against a cartilage disk harvested from stifle joints of 24-week old steers. Test samples and free-swelling control cartilage samples were cultured in Mini ITS medium. Testing was conducted 3 h daily over 10 days applying a contact load of approximately 2 MPa. PG/GAG and hydroxyproline were analyzed using biochemical assays. Additionally, chondrocyte survival and Mankin score analyses were performed on histological slides. Results: Cells stayed alive during the course of the experiment, with cell survival values close to 80% at test completion in the superficial zone. There was no significant difference between AZC and free-swelling control tissue. However, cell count values were inferior for CoCrMo (p = 0.003). Tested tissue suffered mostly structural abnormalities. The PG/GAG content in medium was not different between CoCrMo and AZC (p = 0.315); however, the hydroxyproline release into medium was nearly 30% higher for CoCrMo (p = 0.024). Conclusion: Based on average values, AZC induces less cell and tissue damage than CoCrMo. However, only the hydroxyproline measurements reached statistical significance, partially due to substantial scatter within both groups.
Subjects
Alumina-zirconia-composite
Cartilage
Ceramic
Cobalt-chromium
Defect repair
Hemiarthroplasty
Metal
Wear
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