Publisher DOI: 10.1016/j.jmmm.2019.166206
Title: Simultaneous Magnetic Particle Imaging and Navigation of large superparamagnetic nanoparticles in bifurcation flow experiments
Language: English
Authors: Griese, Florian  
Knopp, Tobias 
Gruettner, Cordula 
Thieben, Florian  
Müller, Knut 
Loges, Sonja 
Ludewig, Peter 
Gdaniec, Nadine 
Keywords: Beads; Bifurcation; Flow velocity; Magnetic Particle Imaging; Magnetic Particle Navigation MPN; Magnetic particles; Micron-sized particles; MPI; Quasi-simultaneously; Stenosis; Superparamagnetic; Targeted drug delivery
Issue Date: 15-Mar-2020
Source: Journal of Magnetism and Magnetic Materials (498): 166206 (2020-03-15)
Abstract (english): 
Magnetic Particle Imaging (MPI) has been successfully used to visualize the distribution of superparamagnetic nanoparticles within 3D volumes with high sensitivity in real time. Since the magnetic field topology of MPI scanners is well suited for applying magnetic forces on particles and micron-sized ferromagnetic devices, MPI has been recently used to navigate micron-sized particles and micron-sized swimmers. In this work, we analyze the magnetophoretic mobility and the imaging performance of two different particle types for Magnetic Particle Imaging/Navigation (MPIN). MPIN constantly switches between imaging and magnetic modes, enabling quasi-simultaneous navigation and imaging of particles. We determine the limiting flow velocity to be 8.18 mL s−1 using a flow bifurcation experiment, that allows all particles to flow only through one branch of the bifurcation. Furthermore, we have succeeded in navigating the particles through the branch of a bifurcation phantom narrowed by either 60% or 100% stenosis, while imaging their accumulation on the stenosis. The particles in combination with therapeutic substances have a high potential for targeted drug delivery and could help to reduce the dose and improve the efficacy of the drug, e.g. for specific tumor therapy and ischemic stroke therapy.
ISSN: 0304-8853
Journal: Journal of magnetism and magnetic materials 
Institute: Biomedizinische Bildgebung E-5 
Document Type: Article
Project: Ganzkörper Magnetic-Particle-Imaging Messsequenzen 
Modellbasierte Parameteridentifikation in Magnetic Particle Imaging 
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