Simultaneous Magnetic Particle Imaging and Navigation of large superparamagnetic nanoparticles in bifurcation flow experiments

Journal
Journal of magnetism and magnetic materials  
Volume
498
Article Number
166206
Citation
Journal of Magnetism and Magnetic Materials (498): 166206 (2020-03-15)
Publisher DOI
10.1016/j.jmmm.2019.166206
Scopus ID
2-s2.0-85075955999
Magnetic Particle Imaging (MPI) has been successfully used to visualize the distribution of superparamagnetic nanoparticles within 3D volumes with high sensitivity in real time. Since the magnetic field topology of MPI scanners is well suited for applying magnetic forces on particles and micron-sized ferromagnetic devices, MPI has been recently used to navigate micron-sized particles and micron-sized swimmers. In this work, we analyze the magnetophoretic mobility and the imaging performance of two different particle types for Magnetic Particle Imaging/Navigation (MPIN). MPIN constantly switches between imaging and magnetic modes, enabling quasi-simultaneous navigation and imaging of particles. We determine the limiting flow velocity to be 8.18 mL s−1 using a flow bifurcation experiment, that allows all particles to flow only through one branch of the bifurcation. Furthermore, we have succeeded in navigating the particles through the branch of a bifurcation phantom narrowed by either 60% or 100% stenosis, while imaging their accumulation on the stenosis. The particles in combination with therapeutic substances have a high potential for targeted drug delivery and could help to reduce the dose and improve the efficacy of the drug, e.g. for specific tumor therapy and ischemic stroke therapy.
Subjects
Beads
Bifurcation
Flow velocity
Magnetic Particle Imaging
Magnetic Particle Navigation MPN
Magnetic particles
Micron-sized particles
MPI
Quasi-simultaneously
Stenosis
Superparamagnetic
Targeted drug delivery