DC FieldValueLanguage
dc.contributor.authorGriese, Florian-
dc.contributor.authorKnopp, Tobias-
dc.contributor.authorGruettner, Cordula-
dc.contributor.authorThieben, Florian-
dc.contributor.authorMüller-Caspary, Knut-
dc.contributor.authorLoges, Sonja-
dc.contributor.authorLudewig, Peter-
dc.contributor.authorGdaniec, Nadine-
dc.date.accessioned2019-12-13T13:25:08Z-
dc.date.available2019-12-13T13:25:08Z-
dc.date.issued2020-03-15-
dc.identifier.citationJournal of Magnetism and Magnetic Materials (498): 166206 (2020-03-15)de_DE
dc.identifier.issn0304-8853de_DE
dc.identifier.urihttp://hdl.handle.net/11420/4098-
dc.description.abstractMagnetic Particle Imaging (MPI) has been successfully used to visualize the distribution of superparamagnetic nanoparticles within 3D volumes with high sensitivity in real time. Since the magnetic field topology of MPI scanners is well suited for applying magnetic forces on particles and micron-sized ferromagnetic devices, MPI has been recently used to navigate micron-sized particles and micron-sized swimmers. In this work, we analyze the magnetophoretic mobility and the imaging performance of two different particle types for Magnetic Particle Imaging/Navigation (MPIN). MPIN constantly switches between imaging and magnetic modes, enabling quasi-simultaneous navigation and imaging of particles. We determine the limiting flow velocity to be 8.18 mL s−1 using a flow bifurcation experiment, that allows all particles to flow only through one branch of the bifurcation. Furthermore, we have succeeded in navigating the particles through the branch of a bifurcation phantom narrowed by either 60% or 100% stenosis, while imaging their accumulation on the stenosis. The particles in combination with therapeutic substances have a high potential for targeted drug delivery and could help to reduce the dose and improve the efficacy of the drug, e.g. for specific tumor therapy and ischemic stroke therapy.en
dc.language.isoende_DE
dc.relation.ispartofJournal of magnetism and magnetic materialsde_DE
dc.subjectBeadsde_DE
dc.subjectBifurcationde_DE
dc.subjectFlow velocityde_DE
dc.subjectMagnetic Particle Imagingde_DE
dc.subjectMagnetic Particle Navigation MPNde_DE
dc.subjectMagnetic particlesde_DE
dc.subjectMicron-sized particlesde_DE
dc.subjectMPIde_DE
dc.subjectQuasi-simultaneouslyde_DE
dc.subjectStenosisde_DE
dc.subjectSuperparamagneticde_DE
dc.subjectTargeted drug deliveryde_DE
dc.titleSimultaneous Magnetic Particle Imaging and Navigation of large superparamagnetic nanoparticles in bifurcation flow experimentsde_DE
dc.typeArticlede_DE
dc.type.diniarticle-
dcterms.DCMITypeText-
tuhh.abstract.englishMagnetic Particle Imaging (MPI) has been successfully used to visualize the distribution of superparamagnetic nanoparticles within 3D volumes with high sensitivity in real time. Since the magnetic field topology of MPI scanners is well suited for applying magnetic forces on particles and micron-sized ferromagnetic devices, MPI has been recently used to navigate micron-sized particles and micron-sized swimmers. In this work, we analyze the magnetophoretic mobility and the imaging performance of two different particle types for Magnetic Particle Imaging/Navigation (MPIN). MPIN constantly switches between imaging and magnetic modes, enabling quasi-simultaneous navigation and imaging of particles. We determine the limiting flow velocity to be 8.18 mL s−1 using a flow bifurcation experiment, that allows all particles to flow only through one branch of the bifurcation. Furthermore, we have succeeded in navigating the particles through the branch of a bifurcation phantom narrowed by either 60% or 100% stenosis, while imaging their accumulation on the stenosis. The particles in combination with therapeutic substances have a high potential for targeted drug delivery and could help to reduce the dose and improve the efficacy of the drug, e.g. for specific tumor therapy and ischemic stroke therapy.de_DE
tuhh.publisher.doi10.1016/j.jmmm.2019.166206-
tuhh.publication.instituteBiomedizinische Bildgebung E-5de_DE
tuhh.type.opus(wissenschaftlicher) Artikel-
dc.type.driverarticle-
dc.type.casraiJournal Article-
tuhh.container.volume498de_DE
dc.relation.projectGanzkörper Magnetic-Particle-Imaging Messsequenzende_DE
dc.relation.projectModellbasierte Parameteridentifikation in Magnetic Particle Imagingde_DE
dc.identifier.scopus2-s2.0-85075955999-
tuhh.container.articlenumber166206de_DE
local.status.inpressfalsede_DE
item.creatorOrcidGriese, Florian-
item.creatorOrcidKnopp, Tobias-
item.creatorOrcidGruettner, Cordula-
item.creatorOrcidThieben, Florian-
item.creatorOrcidMüller-Caspary, Knut-
item.creatorOrcidLoges, Sonja-
item.creatorOrcidLudewig, Peter-
item.creatorOrcidGdaniec, Nadine-
item.languageiso639-1en-
item.creatorGNDGriese, Florian-
item.creatorGNDKnopp, Tobias-
item.creatorGNDGruettner, Cordula-
item.creatorGNDThieben, Florian-
item.creatorGNDMüller-Caspary, Knut-
item.creatorGNDLoges, Sonja-
item.creatorGNDLudewig, Peter-
item.creatorGNDGdaniec, Nadine-
item.openairetypeArticle-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.mappedtypeArticle-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptBiomedizinische Bildgebung E-5-
crisitem.author.deptBiomedizinische Bildgebung E-5-
crisitem.author.deptBiomedizinische Bildgebung E-5-
crisitem.author.deptBiomedizinische Bildgebung E-5-
crisitem.author.orcid0000-0003-3309-9783-
crisitem.author.orcid0000-0002-1589-8517-
crisitem.author.orcid0000-0002-2890-5288-
crisitem.author.orcid0000-0002-2588-7993-
crisitem.author.orcid0000-0001-9025-6402-
crisitem.author.orcid0000-0002-5060-0683-
crisitem.author.parentorgStudiendekanat Elektrotechnik, Informatik und Mathematik-
crisitem.author.parentorgStudiendekanat Elektrotechnik, Informatik und Mathematik-
crisitem.author.parentorgStudiendekanat Elektrotechnik, Informatik und Mathematik-
crisitem.author.parentorgStudiendekanat Elektrotechnik, Informatik und Mathematik-
crisitem.project.funderDeutsche Forschungsgemeinschaft (DFG)-
crisitem.project.funderBundesministerium für Bildung und Forschung (BMBF)-
crisitem.project.funderid501100001659-
crisitem.project.funderid501100002347-
crisitem.project.funderrorid018mejw64-
crisitem.project.funderrorid04pz7b180-
crisitem.project.grantnoKN 1108/2-1-
crisitem.project.grantno05M16GKA-
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